Document Detail


What can we learn from erythrocyte Na-K-Cl cotransporter NKCC1 in human hypertension?
MedLine Citation:
PMID:  17942286     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Fluxes catalyzed by the human Na-K-Cl cotransporter NKCC1 (hNKCC1) were extensively investigated in erythrocytes from essential hypertensive patients. Using different techniques, four hNKCC1 abnormalities were described in a significant proportion of hypertensives: (i) low net sodium extrusion, (ii) high unidirectional inward cotransport, (iii) low apparent affinity for internal sodium and (iv) high maximal cotransport rate. All these four hNKCC1 abnormalities are compatible with an increased net inward cotransport. In hypertensive rat models, an increased net inward cotransport drives more chloride inside the cells, favoring membrane depolarization and hypertension. NKCC1 knock out mice are hypotensive and exhibit a compensatory elevation in renin secretion, apparently due to the lack of a functional NKCC1 in juxtaglomerular granular cells, which normally reduces basal renin release. This latter hypothesis is supported by the observation that human hypertensives with high cotransport have low renin hypertension and increased salidiuretic response to furosemide. Therefore, the human erythrocyte data validates animal studies showing increased net inward fluxes by NKCC1 in primary hypertension.
Authors:
Ricardo P Garay; Octavio Alda
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Publication Detail:
Type:  Journal Article     Date:  2007-10-17
Journal Detail:
Title:  Pathophysiology : the official journal of the International Society for Pathophysiology / ISP     Volume:  14     ISSN:  0928-4680     ISO Abbreviation:  Pathophysiology     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433813     Medline TA:  Pathophysiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  167-70     Citation Subset:  -    
Affiliation:
EA2381, University Paris VII, Paris, France.
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