Document Detail

What is bad in cancer is good in the embryo: importance of EMT in neural crest development.
MedLine Citation:
PMID:  22430756     Owner:  NLM     Status:  MEDLINE    
Although the epithelial to mesenchymal transition (EMT) is famous for its role in cancer metastasis, it also is a normal developmental event in which epithelial cells are converted into migratory mesenchymal cells. A prime example of EMT during development occurs when neural crest (NC) cells emigrate from the neural tube thus providing an excellent model to study the principles of EMT in a nonmalignant environment. NC cells start life as neuroepithelial cells intermixed with precursors of the central nervous system. After EMT, they delaminate and begin migrating, often to distant sites in the embryo. While proliferating and maintaining multipotency and cell survival the transitioning neural crest cells lose apicobasal polarity and the basement membrane is broken down. This review discusses how these events are coordinated and regulated, by series of events involving signaling factors, gene regulatory interactions, as well as epigenetic and post-transcriptional modifications. Even though the series of events involved in NC EMT are well known, the sequence in which these steps take place remains a subject of debate, raising the intriguing possibility that, rather than being a single event, neural crest EMT may involve multiple parallel mechanisms.
Laura Kerosuo; Marianne Bronner-Fraser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-10
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  23     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-11-13     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  320-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Division of Biology, California Institute of Technology, Pasadena, CA 91125, United States.
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MeSH Terms
Cell Movement
Epithelial Cells / cytology*
Epithelial-Mesenchymal Transition / physiology*
Mesoderm / cytology*
Neoplasms / pathology*
Neural Crest / cytology*,  embryology
Grant Support
DE017911/DE/NIDCR NIH HHS; HD037105/HD/NICHD NIH HHS; R01 DC011577-01A1/DC/NIDCD NIH HHS; R01 DC011577-02/DC/NIDCD NIH HHS; R01 DE016459-10A2/DE/NIDCR NIH HHS; R01 DE016459-11/DE/NIDCR NIH HHS

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