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What are a patient's current chances of finding a matched unrelated donor? Twenty years' central search experience in a small country.
MedLine Citation:
PMID:  21460872     Owner:  NLM     Status:  Publisher    
Between 1988 and 2007, international searches for matched unrelated donors (MUDs) were performed for 1586 Austrian patients. Between 2004 and 2007, a MUD was identified for 76.7% of the patients. Between 1996 and 2003, a donor was identified for 71.3% of the patients, and between 1988 and 1995, only for 53.4% of the patients. Search times of successful searches decreased from 7.7 months in the first period to 1.7 months in the period from 2004 to 2007. However, transplants were not performed in all cases in which a donor was found: only in 61.6% of the patients between 2004 and 2007, in 53.4% between 1996 and 2003 and in 29.6% between 1988 and 1995. Multivariate analysis determined that having a common HLA type was the most important variable impacting on finding a MUD for a patient. Factors that most strongly influence a patient's access to transplant were the patient's European origin and a short time between diagnosis and start of donor search. The strongest factor for both finding a donor and being transplanted was a search being performed during more recent years: patients' chances increased from year to year.Bone Marrow Transplantation advance online publication, 4 April 2011; doi:10.1038/bmt.2011.67.
A Rosenmayr; M Pointner-Prager; A Mitterschiffthaler; L Bozic; B Pelzmann; H Tüchler; I Fae; G F Fischer; H T Greinix; Ch Peters; P Kalhs; O Krieger; W Linkesch; D Nachbaur; Ch Urban; U Posch; G Lanzer; Ch Gabriel; H Schennach; W R Mayr
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-04
Journal Detail:
Title:  Bone marrow transplantation     Volume:  -     ISSN:  1476-5365     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] Department of Blood Group Serology, Medical University of Vienna, Vienna, Austria [2] Austrian Bone Marrow Donor Registry, Vienna, Austria.
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