Document Detail

What are melanocytes really doing all day long...?
MedLine Citation:
PMID:  19659579     Owner:  NLM     Status:  MEDLINE    
Everyone knows and seems to agree that melanocytes are there to generate melanin - an intriguing, but underestimated multipurpose molecule that is capable of doing far more than providing pigment and UV protection to skin (1). What about the cell that generates melanin, then? Is this dendritic, neural crest-derived cell still serving useful (or even important) functions when no-one looks at the pigmentation of our skin and its appendages and when there is essentially no UV exposure? In other words, what do epidermal and hair follicle melanocytes do in their spare time - at night, under your bedcover? How much of the full portfolio of physiological melanocyte functions in mammalian skin has really been elucidated already? Does the presence or absence of melanocytes matter for normal epidermal and/or hair follicle functions (beyond pigmentation and UV protection), and for skin immune responses? Do melanocytes even deserve as much credit for UV protection as conventional wisdom attributes to them? In which interactions do these promiscuous cells engage with their immediate epithelial environment and who is controlling whom? What lessons might be distilled from looking at lower vertebrate melanophores and at extracutaneous melanocytes in the endeavour to reveal the 'secret identity' of melanocytes? The current Controversies feature explores these far too infrequently posed, biologically and clinically important questions. Complementing a companion viewpoint essay on malignant melanocytes (2), this critical re-examination of melanocyte biology provides a cornucopia of old, but under-appreciated concepts and novel ideas on the slowly emerging complexity of physiological melanocyte functions, and delineates important, thought-provoking questions that remain to be definitively answered by future research.
P M Plonka; T Passeron; M Brenner; D J Tobin; S Shibahara; A Thomas; A Slominski; A L Kadekaro; D Hershkovitz; E Peters; J J Nordlund; Z Abdel-Malek; K Takeda; R Paus; J P Ortonne; V J Hearing; K U Schallreuter
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-07-30
Journal Detail:
Title:  Experimental dermatology     Volume:  18     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-12-28     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  799-819     Citation Subset:  IM    
Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, PL-30-387 Kraków, Poland.
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MeSH Terms
Epidermis / physiology
Keratinocytes / physiology
Melanins / biosynthesis
Melanocytes / physiology*
Grant Support
Reg. No./Substance:
Erratum In:
Exp Dermatol. 2009 Dec;18(12):1096

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