Document Detail


What are the mechanisms for analogue and digital signalling in the brain?
MedLine Citation:
PMID:  23187813     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Synaptic transmission in the brain generally depends on action potentials. However, recent studies indicate that subthreshold variation in the presynaptic membrane potential also determines spike-evoked transmission. The informational content of each presynaptic action potential is therefore greater than initially expected. The contribution of this synaptic property, which is a fast (from 0.01 to 10 s) and state-dependent modulation of functional coupling, has been largely underestimated and could have important consequences for our understanding of information processing in neural networks. We discuss here how the membrane voltage of the presynaptic terminal might modulate neurotransmitter release by mechanisms that do not involve a change in presynaptic Ca(2+) influx.
Authors:
Dominique Debanne; Andrzej Bialowas; Sylvain Rama
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-28
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  -     ISSN:  1471-0048     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
INSERM, UMR_S 1072, and Aix-Marseille Université, UNIS, 13015, Marseille, France.
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