Document Detail

What are the cut-off levels for IL-6 and CRP in neonatal sepsis?
MedLine Citation:
PMID:  21089127     Owner:  NLM     Status:  In-Process    
Neonatal sepsis, characterized by systemic signs of infection in the first month of life, remains an important clinical syndrome. Despite advances in neonatology, it has high rates of mortality and morbidity. The combine or alone usage of interleukin-6 (IL-6) and C-reactive protein (CRP) has recently been proven to be useful in the early diagnosis of sepsis in newborns. The study included 282 patients; there were 232 in Group I (170 proven and 62 clinical sepsis) and 50 in Group II (control group). The optimum cut-off value in the diagnosis of neonatal sepsis was found to be 24.65 pg/ml for IL-6 and 4.82 mg/l for CRP. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of this IL-6 cut-off for neonatal sepsis were 72, 84, 95, and 42%, respectively. Sensitivity, specificity, PPV, and NPV of the CRP cut-off for neonatal sepsis were 67, 97, 99, and 39%, respectively. The combination of IL-6 (>24.65 pg/ml) and CRP (>4.82 mg/l) in the diagnosis of neonatal sepsis gave sensitivity, specificity, PPV, and NPV of 53, 100, 100, and 33%, respectively. To our knowledge, this is the largest reported study seeking to determine cut-off levels for IL-6 and CRP in the diagnosis of neonatal sepsis. In conclusion, we think that it is useful to evaluate IL-6 and CRP, in combination, for the early diagnosis of neonatal sepsis.
Istemi Han Celik; Fatma Gamze Demirel; Nurdan Uras; Serife Suna Oguz; Omer Erdeve; Zeynep Biyikli; Ugur Dilmen
Related Documents :
7017907 - Colonization of newborns with group b streptococci: relation to maternal urogenital car...
21295927 - Movements and postures of infants aged 3 to 5 months: to what extent is their optimalit...
10749467 - Umbilical vein interleukin 6 and tumor necrosis factor alpha plasma concentrations in t...
21150647 - Supplementation of infant formula with probiotics and/or prebiotics: a systematic revie...
3946377 - Does breastfeeding really save lives, or are apparent benefits due to biases?
11706957 - Association of streptococcus mutans infection and oral developmental nodules in pre-den...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  24     ISSN:  1098-2825     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  407-12     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
Division of Neonatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Concise review: stem cells as an emerging platform for antibody therapy of cancer.
Next Document:  Associations between dietary flavonoid intakes and bone health in a Scottish population.