| What are RBC-transfusion-dependence and -independence? | |
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MedLine Citation:
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PMID: 20692036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The term RBC-transfusion-dependence is widely-used by hematologists to describe a condition of severe anemia typically arising when erythropoiesis is reduced such that a person continuously requires ≥1 RBC-transfusions over a specified interval. Defining a person as RBC-transfusion-dependent has important implications in diverse hematological disorders especially because it strongly-correlated with decreased survival. Conversely, becoming RBC-transfusion-independent or receiving fewer RBC-transfusions over a specified interval is defined as improvement or response in many disease- and/or therapy-setting. Whether this correlates with improved survival is controversial. We used a structured expert-panel consensus panel process to define RBC-transfusion-dependence and -independence or improvement. We suggest these definitions may prove useful to persons studying or treating these diseases. |
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Authors:
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R P Gale; G Barosi; T Barbui; F Cervantes; K Dohner; B Dupriez; V Gupta; C Harrison; R Hoffman; J-J Kiladjian; R Mesa; M F Mc Mullin; F Passamonti; V Ribrag; G Roboz; G Saglio; A Vannucchi; S Verstovsek |
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Publication Detail:
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Type: Letter Date: 2010-08-07 |
Journal Detail:
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Title: Leukemia research Volume: 35 ISSN: 1873-5835 ISO Abbreviation: Leuk. Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 8-11 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Imperial College London, Section of Haematology, Division of Experimental Medicine, Department of Medicine, London, UK. robertpetergale@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Delphi Technique Erythrocyte Transfusion* Humans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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