Document Detail

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements.
MedLine Citation:
PMID:  25322670     Owner:  NLM     Status:  Publisher    
Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701 articles which we appraised in detail. Impaired skin barrier function and increased vascular reactivity are most often associated with sensitive skin. We identified key reasons causing an ambiguity around the sensitive skin phenomenon. We propose using standardized selection methods of subjects by a multifactorial questionnaire spanning a range of provocations, including those of chemical, mechanical and environmental origin, followed by clinical, histological and top-notch biophysical measurements. This could lead to a breakthrough in the understanding of the sensitive skin phenomenon, fueling advances of biomedical and dermatological science. © 2014 S. Karger AG, Basel.
Renée Richters; Denise Falcone; Natallia Uzunbajakava; Willem Verkruysse; Piet van Erp; Peter van de Kerkhof
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-14
Journal Detail:
Title:  Skin pharmacology and physiology     Volume:  28     ISSN:  1660-5535     ISO Abbreviation:  Skin Pharmacol Physiol     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-17     Completed Date:  -     Revised Date:  2014-10-18    
Medline Journal Info:
Nlm Unique ID:  101188418     Medline TA:  Skin Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  75-83     Citation Subset:  -    
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