Document Detail

What patients with gilles de la tourette syndrome should be treated with deep brain stimulation and what is the best target?
MedLine Citation:
PMID:  22407075     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gilles de la Tourette syndrome (GTS) is a chronic neurodevelopmental disorder characterized by tics and associated behavioral symptoms. Over the past decade, deep brain stimulation (DBS) has been increasingly advocated as a reversible and controllable procedure for selected cases of GTS.
OBJECTIVE: We set out to answer 2 clinically relevant questions: what patients with GTS should be treated with DBS and what is the best target?
METHODS: We conducted a systematic literature review of the published studies of DBS in GTS and critically evaluated the current evidence for both patient and target selection.
RESULTS: Since 1999, up to 99 cases of DBS in GTS have been reported in the scientific literature, with varying selection criteria, stimulation targets, and assessment protocols. The vast majority of studies published to date are case reports or case series reporting successful outcomes in terms of both tic severity improvement and tolerability. The reviewed studies suggest that the best candidates are patients with significant functional impairment related to the tic symptoms, who did not respond to conventional pharmacological and behavioral interventions. The globus pallidus internus and thalamus appear to be the safest and most effective targets, especially for patients with "pure" GTS and patients with comorbid obsessive-compulsive symptoms, anxiety, and depression.
CONCLUSION: DBS is a promising treatment option for severe cases of GTS. There is a need to reach consensus on the definition of "treatment-refractoriness" and to conduct larger double-blind randomized controlled studies on the most promising targets.
John Carlo Pansaon Piedad; Hugh Edward Rickards; Andrea Eugenio Cavanna
Related Documents :
20307485 - Painful and tender toe, osteoid osteoma of the distal phalanx of toe, a diagnostic dile...
1828815 - Pigmented postacne osteoma cutis in a patient treated with minocycline: report and revi...
22494495 - A retrospective case review of isolated sinonasal amyloidosis.
16023225 - A huge osteoma of the middle ear.
7104945 - Is stuttering a contraindication to psychotherapy?
8797445 - Torulopsis pneumonia. a case report and review of the literature.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgery     Volume:  71     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-19     Completed Date:  2012-10-30     Revised Date:  2013-01-11    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-92     Citation Subset:  IM    
Michael Trimble Neuropsychiatry Research Group, Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age of Onset
Brain / physiology*
Databases, Bibliographic / statistics & numerical data
Deep Brain Stimulation / methods*
Tourette Syndrome / diagnosis,  physiopathology,  therapy*
Comment In:
Neurosurgery. 2012 Jul;71(1):192-3   [PMID:  22893916 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Short-term Complications Associated with Surgery for High-grade Spondylolisthesis in Adults and Pedi...
Next Document:  Protein profiling of keloidal scar tissue.