Document Detail

What is the optimal postconditioning algorithm?
MedLine Citation:
PMID:  19741111     Owner:  NLM     Status:  MEDLINE    
Ischemic postconditioning has emerged as a clinically feasible intervention for limiting infarction in the setting of percutaneous intervention. In ischemic postconditioning, a number of cycles of a brief period of reperfusion followed by a brief period of occlusion are applied immediately upon reperfusion of the ischemic heart. Although ischemic postconditioning is protective in both animals and man, the animal studies reveal that the algorithm used in selecting the duration of the occlusion and reperfusion periods is critical to the degree of protection realized and it varies with species. The question then arises what is the best algorithm for man? The available animal and clinical data are examined in an attempt to shed light on this perplexing problem.
Efstathios K Iliodromitis; James M Downey; Gerd Heusch; Dimitrios T Kremastinos
Publication Detail:
Type:  Editorial     Date:  2009-09-09
Journal Detail:
Title:  Journal of cardiovascular pharmacology and therapeutics     Volume:  14     ISSN:  1940-4034     ISO Abbreviation:  J. Cardiovasc. Pharmacol. Ther.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-11     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602617     Medline TA:  J Cardiovasc Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  IM    
2nd University Department of Cardiology, Medical School, Attikon General Hospital, University of Athens, Athens, Greece.
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MeSH Terms
Ischemic Preconditioning, Myocardial / methods*
Myocardial Infarction / prevention & control*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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