| What Have Genome-Wide Studies Told Us About Psoriatic Arthritis? | |
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MedLine Citation:
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PMID: 22532288 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is convincing evidence to suggest a strong genetic component to psoriatic arthritis (PsA), with studies reporting a 40-fold risk to first-degree relatives of patients with disease. However, compared with rheumatoid arthritis, our understanding of the genetic etiology of PsA is less well-developed. Only three modestly sized genome-wide association studies of PsA have been undertaken to date, but they have identified the HLA-C region, IL12B, TRAF3IP2, and FBXL19 genes as being associated with PsA susceptibility. Results of genome-wide association studies of psoriasis and rheumatoid arthritis have been used to identify candidate genes for subsequent testing in PsA and have led to the identification of additional susceptibility factors for PsA. Most show overlap with psoriasis, whereas the overlap with rheumatoid arthritis is less pronounced. However, two loci show strong evidence for association with PsA but not psoriasis: HLA-B27 and the IL-13 gene locus. |
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Authors:
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James Bluett; Anne Barton |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-25 |
Journal Detail:
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Title: Current rheumatology reports Volume: - ISSN: 1534-6307 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888970 Medline TA: Curr Rheumatol Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Arthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester, England, M13 9PT, UK, jbluett@nhs.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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