Document Detail


What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders.
MedLine Citation:
PMID:  21259123     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The consequences of fetal exposure to alcohol are very diverse and the likely molecular mechanisms involved must be able to explain how so many developmental processes could go awry. If pregnant rat dams are fed alcohol, their pups develop abnormalities characteristic of fetal alcohol spectrum disorders (FASD), but if these rat dams were also treated with choline, the effects from ethanol were attenuated in their pups. Choline is an essential nutrient in humans, and is an important methyl group donor. Alcohol exposure disturbs the metabolism of choline and other methyl donors. Availability of choline during gestation directly influences epigenetic marks on DNA and histones, and alters gene expression needed for normal neural and endothelial progenitor cell proliferation. Maternal diets low in choline alter development of the mouse hippocampus, and decrement memory for life. Women eating low-choline diets have an increased risk of having an infant with a neural tube or orofacial cleft birth defect. Thus, the varied effects of choline could affect the expression of FASD, and studies on choline might shed some light on the underlying molecular mechanisms responsible for FASD.
Authors:
Steven H Zeisel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-01-25
Journal Detail:
Title:  Molecular neurobiology     Volume:  44     ISSN:  1559-1182     ISO Abbreviation:  Mol. Neurobiol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-01-23     Revised Date:  2014-04-17    
Medline Journal Info:
Nlm Unique ID:  8900963     Medline TA:  Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Choline / metabolism*
Diet
Epigenesis, Genetic
Ethanol / adverse effects*
Female
Fetal Alcohol Spectrum Disorders / metabolism*,  physiopathology*
Humans
Pregnancy
Grant Support
ID/Acronym/Agency:
DK55865/DK/NIDDK NIH HHS; DK56350/DK/NIDDK NIH HHS; P30 DK056350/DK/NIDDK NIH HHS; P30 ES010126/ES/NIEHS NIH HHS; R01 DK055865/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
3K9958V90M/Ethanol; N91BDP6H0X/Choline
Comments/Corrections

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