| What can current stimulation tell us about the vascular function of endogenous prostacyclin in healthy rat skin in vivo? | |
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MedLine Citation:
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PMID: 20827283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In endothelial function, prostacyclin (PGI(2)) is as important as nitric oxide (NO); however, no test assesses specifically the vascular function of endogenous PGI(2). We hypothesized that PGI(2) has a dominant role in cathodal current-induced vasodilation (CIV) described in human skin. We thus aimed to study, in physiological conditions, the PGI(2) involvement in cathodal CIV in rats in order to use pharmacological blockers that could not be used in humans. CIV was reduced by cyclooxygenase (COX)-1 and PGI(2) synthase (PGIS) and PGI(2) receptor (IP) blockers, but was unchanged by COX-2 and NO synthase (NOS) blockers. The level of 6-ketoPGF(1)(α) present in skin biopsies, measured as endogenous PGI(2), was increased by cathodal current stimulation, except under COX-1 and PGIS inhibition. This study provides evidence that cathodal CIV mainly relies on the release of PGI(2) endogenously produced through the COX-1/PGIS pathway, and then acts on IP receptors to relax the cutaneous microvessels in healthy rats. In contrast, neither COX-2 nor NOS is involved in CIV and the endogenous PGI(2) release by current stimulation. This finding shows that cathodal current stimulation could be a valuable method to assess the vascular function of endogenous PGI(2) in healthy skin. |
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Authors:
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Stéphanie Gohin; Dominique Sigaudo-Roussel; Agnès Conjard-Duplany; Laurence Dubourg; Jean Louis Saumet; Bérengère Fromy |
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Publication Detail:
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Type: Journal Article Date: 2010-09-09 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 131 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-15 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 237-44 Citation Subset: IM |
Affiliation:
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Neurovascular Interactions, FRE CNRS 3075, Institut des Sciences Biologiques et Pharmaceutiques, Université Claude Bernard Lyon 1, Lyon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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metabolism Acetylcholine / pharmacology Animals Biopsy Cyclooxygenase 1 / metabolism Cyclooxygenase 2 / metabolism Cyclooxygenase Inhibitors / pharmacology Electric Stimulation* Epoprostenol / physiology* Galvanic Skin Response / physiology Male Nitric Oxide Synthase / metabolism Rats Rats, Wistar Skin / blood supply*, drug effects, radiation effects Skin Physiological Processes* Vasodilation / physiology*, radiation effects Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Vasodilator Agents; 35121-78-9/Epoprostenol; 51-84-3/Acetylcholine; 58962-34-8/6-Ketoprostaglandin F1 alpha; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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