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What is the Background Incidence of Malignancy in Children with Rheumatic Disease?
MedLine Citation:
PMID:  23378144     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Until recently, relatively little was known about the background risk of malignancy in pediatric rheumatic diseases. Worrying reports about the development of malignancies in children treated with new biologic agents have prompted rigorous studies of the incidence of malignancy associated with juvenile idiopathic arthritis (JIA). These studies reveal that JIA is likely to be associated with an increased risk of incident malignancy, irrespective of treatment with new biologic agents. A preliminary study indicates that the background risk of malignancy is also elevated in pediatric-onset systemic lupus erythematosus. On the basis of simple observation, the background risk of malignancy among children with Sjögren syndrome and dermatomyositis seems much lower than the markedly elevated risk found in adults with the same diagnoses. Clearly, the background risk of malignancy must be considered in any evaluation of the safety of new therapeutic agents.
Authors:
Melissa L Mannion; Timothy Beukelman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current rheumatology reports     Volume:  15     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  310     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Rheumatology, The University of Alabama at Birmingham, Children's Park Place 210, 1600 7th Ave South, Birmingham, AL, 35233, USA, mmannion@peds.uab.edu.
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