| Wewakamide A and Guineamide G, Cyclic Depsipeptides from the Marine Cyanobacteria Lyngbya semiplena and Lyngbya majuscula. | |
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MedLine Citation:
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PMID: 21952369 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Two new cyclic depsipeptides wewakamide A (1) and guineamide G (2) have been isolated from the marine cyanobacterium Lyngbya semiplena and Lyngbya majuscula, respectively, collected from Papua New Guinea. The amino and hydroxy acid partial structures of wewakamide A and guineamide G were elucidated through extensive spectroscopic techniques, including HR-FABMS, 1D 1H and 13C NMR, as well as 2D COSY, HSQC, HSQCTOCSY, and HMBC spectra. The sequence of the residues of wewakamide A was determined through a combination of ESI-MS/MS, HMBC, and ROESY. Wewakamide A possesses a beta-amino acid, 3-amino-2-methylbutanoic acid (Maba) residue, which has only been previously identified in two natural products, guineamide B (3) and dolastatin D (4). Although both new compounds (1,2) showed potent brine shrimp toxicity, only guineamide G displayed significant cytotoxicity to a mouse neuroblastoma cell line with LC50 values of 2.7 micrometer. |
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Authors:
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Bingnan Han; Harald Gross; Kerry L McPhail; Doug Goeger; Claudia S Maier; William H Gerwick |
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Publication Detail:
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Type: - |
Journal Detail:
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Title: Journal of microbiology and biotechnology Volume: 21 ISSN: 1738-8872 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431852 Medline TA: J Microbiol Biotechnol Country: - |
Other Details:
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Languages: ENG Pagination: 930-936 Citation Subset: - |
Affiliation:
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Department of Ocean Science and Engineering, Zhejiang University, Hangzhou, China 310028. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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