Document Detail

Wettability influences cell behavior on superhydrophobic surfaces with different topographies.
MedLine Citation:
PMID:  22833364     Owner:  NLM     Status:  In-Data-Review    
Surface wettability and topography are recognized as critical factors influencing cell behavior on biomaterials. So far only few works have reported cell responses on surfaces exhibiting extreme wettability in combination with surface topography. The goal of this work is to study whether cell behavior on superhydrophobic surfaces is influenced by surface topography and polymer type. Biomimetic superhydrophobic rough surfaces of polystyrene and poly(L: -lactic acid) with different micro/nanotopographies were obtained from smooth surfaces using a simple phase-separation based method. Total protein was quantified and showed a less adsorption of bovine serum albumin onto rough surfaces as compared to smooth surfaces of the same material. The mouse osteoblastic MC3T3-E1 cell line and primary bovine articular chondrocytes were used to study cell attachment and proliferation. Cells attached and proliferate better in the smooth surfaces. The superhydrophobic surfaces allowed cells to adhere but inhibited their proliferation. This study indicates that surface wettability, rather than polymer type or the topography of the superhydrophobic surfaces, is a critical factor in determining cell behavior.
Bianca N Lourenço; Giulia Marchioli; Welong Song; Rui L Reis; Clemens A van Blitterswijk; Marcel Karperien; Aart van Apeldoorn; João F Mano
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Publication Detail:
Type:  Journal Article     Date:  2012-07-26
Journal Detail:
Title:  Biointerphases     Volume:  7     ISSN:  1559-4106     ISO Abbreviation:  Biointerphases     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101275679     Medline TA:  Biointerphases     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46     Citation Subset:  IM    
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, 4806-909, Taipas, Guimarães, Portugal.
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