| A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. | |
| | |
MedLine Citation:
|
PMID: 21088217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Epidemiological studies have provided evidence suggesting an important role for diet and obesity in the development of cancer. Specifically, lipid nutrients of the diet have been identified as important regulators of tumor development and progression. In the present study, we have examined the role of dietary fat and cholesterol in the initiation and progression of prostate cancer using the well-characterized TRAMP mouse model. Consumption of a Western-type diet--that is, enriched in both fat and cholesterol--accelerated prostate tumor incidence and tumor burden compared to mice fed a control chow diet. Furthermore, we also show that this diet increased the extent and the histological grade of prostate tumors. These findings were confirmed by the presence of increased levels of protein markers of advanced tumors in prostates obtained from animals fed a Western-type diet compared to those obtained from control animals. Increased lung metastases in animals fed a Western-type diet were also observed. In addition, we found that with a Western diet, animals bearing tumors presented with reduced plasma cholesterol levels compared with animals fed a control diet. Finally, we show that tumors obtained from animals fed a Western-type diet displayed increased expression of the high-density lipoprotein receptor SR-BI and increased angiogenesis. Taken together, our data suggest that dietary fat and cholesterol play an important role in the development of prostate cancer. |
| | |
Authors:
|
Gemma Llaverias; Christiane Danilo; Yu Wang; Agnes K Witkiewicz; Kristin Daumer; Michael P Lisanti; Philippe G Frank |
Related Documents
:
|
728877 - Metabolic epidemiology of large bowel cancer: fecal bulk and constituents of high-risk ... 17052997 - The effect of haem in red and processed meat on the endogenous formation of n-nitroso c... 16313697 - Micronutrients: dietary intake v. supplement use. 8649207 - Polyamine deprivation provokes an antalgic effect. 7163107 - The nutritional value of moldy grains for broiler chicks. 22440467 - Effects of dietary lipids and clostridium butyricum on serum lipids and lipid-related g... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-18 |
Journal Detail:
|
Title: The American journal of pathology Volume: 177 ISSN: 1525-2191 ISO Abbreviation: Am. J. Pathol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-01 Completed Date: 2011-03-15 Revised Date: 2011-12-21 |
Medline Journal Info:
|
Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 3180-91 Citation Subset: AIM; IM |
Affiliation:
|
Department of Stem Cell Biology and Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, 233 S. 10th Street, Philadelphia, PA 19107, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
blood,
etiology,
metabolism,
pathology* Animals Cell Proliferation / drug effects Diet / adverse effects* Dietary Fats / adverse effects, pharmacology Disease Models, Animal Disease Progression Lung Neoplasms / secondary Male Mice Mice, Inbred C57BL Mice, Transgenic Prostatic Neoplasms / blood, etiology, metabolism, pathology* Tumor Burden Western World |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats |
| Comments/Corrections | |
Erratum In:
|
Am J Pathol. 2011 Mar;178(3):1406 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signali...
Next Document: Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascul...