Document Detail


West Nile virus-induced bax-dependent apoptosis.
MedLine Citation:
PMID:  11434919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of cell death induced by West Nile virus (WNV), a causative agent of human febrile syndrome and encephalitis, was investigated. WNV-infected K562 and Neuro-2a cells manifested the typical features of apoptosis, including cell shrinkage, chromatin condensation and subdiploid DNA content by flow cytometry. DNA fragmentation into nucleosomal size and changes in outer cell membrane phospholipid composition were also observed in K562 cells. UV-inactivated virus failed to induce the above-mentioned characteristics, suggesting that viral replication may be required for the induction of apoptosis by WNV. Additionally, signals involved in WNV-induced apoptosis are associated with the up-regulation of bax gene expression.
Authors:
M C Parquet; A Kumatori; F Hasebe; K Morita; A Igarashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  500     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-03     Completed Date:  2001-07-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  17-24     Citation Subset:  IM    
Affiliation:
Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aedes
Animals
Apoptosis / physiology*
Cell Survival / physiology
Humans
K562 Cells / cytology*,  virology
Proto-Oncogene Proteins / biosynthesis*,  genetics,  physiology
Proto-Oncogene Proteins c-bcl-2*
RNA, Messenger / metabolism
Tumor Cells, Cultured
Up-Regulation
West Nile virus / physiology*
bcl-2-Associated X Protein
Chemical
Reg. No./Substance:
0/BAX protein, human; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/RNA, Messenger; 0/bcl-2-Associated X Protein

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