Document Detail


Wernicke encephalopathy following splenectomy in a patient with liver cirrhosis: a case report and review of the literature.
MedLine Citation:
PMID:  20506574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To report a case of Wernicke encephalopathy in the early stage after surgery.
METHODS: A nonalcoholic female patient with hepatitis B-related cirrhosis and hypersplenism underwent splenectomy in a local hospital. No surgical complications occurred and the patient recovered well. However, on the eighth postoperative day she developed psychiatric and neurological disturbance without an obvious cause. She was then admitted to our hospital. Brain magnetic resonance imaging (MRI) with FLAIR T2 showed symmetric high-signal intensities in the periaqueductal area of the midbrain, which were consistent with Wernicke encephalopathy. She was thus given intramuscular thiamine immediately.
RESULTS: After the administration of thiamine, the patient's confused mental state resolved within 3 d, and her dystaxia gradually improved over the next 5 d. The brain MRI with FLAIR T2 was re-examined one month after the episode, and showed nearly complete resolution of the previously abnormal signal intensities in the periaqueductal area of the midbrain.
CONCLUSION: Physicians should be aware of the possibility of acute Wernicke encephalopathy, especially in patients with liver dysfunction.
Authors:
Xia-ping Zhang; Yuan-qiang Lu; Wei-dong Huang
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  11     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-10-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  433-6     Citation Subset:  IM    
Affiliation:
Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Liver Cirrhosis / complications*,  surgery*
Middle Aged
Splenectomy / adverse effects*
Wernicke Encephalopathy / diagnosis*,  etiology*,  prevention & control
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