Document Detail

Wernicke encephalopathy following splenectomy in a patient with liver cirrhosis: a case report and review of the literature.
MedLine Citation:
PMID:  20506574     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of Wernicke encephalopathy in the early stage after surgery.
METHODS: A nonalcoholic female patient with hepatitis B-related cirrhosis and hypersplenism underwent splenectomy in a local hospital. No surgical complications occurred and the patient recovered well. However, on the eighth postoperative day she developed psychiatric and neurological disturbance without an obvious cause. She was then admitted to our hospital. Brain magnetic resonance imaging (MRI) with FLAIR T2 showed symmetric high-signal intensities in the periaqueductal area of the midbrain, which were consistent with Wernicke encephalopathy. She was thus given intramuscular thiamine immediately.
RESULTS: After the administration of thiamine, the patient's confused mental state resolved within 3 d, and her dystaxia gradually improved over the next 5 d. The brain MRI with FLAIR T2 was re-examined one month after the episode, and showed nearly complete resolution of the previously abnormal signal intensities in the periaqueductal area of the midbrain.
CONCLUSION: Physicians should be aware of the possibility of acute Wernicke encephalopathy, especially in patients with liver dysfunction.
Xia-ping Zhang; Yuan-qiang Lu; Wei-dong Huang
Related Documents :
15315294 - Carbon disulfide neurotoxicity: taiwan experience.
20634304 - Basal ganglia involvement in wernicke encephalopathy: report of 2 cases.
8954304 - Chronic carbon disulfide encephalopathy.
14696484 - Mr and 1h mr spectroscopy of the brain in patients with liver cirrhosis and early stage...
24972954 - Mr-sequences for prostate cancer diagnostics: validation based on the pi-rads scoring s...
11240824 - Magnetic resonance imaging and morphometric histologic analysis of prostate tissue comp...
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  11     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-10-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  433-6     Citation Subset:  IM    
Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Liver Cirrhosis / complications*,  surgery*
Middle Aged
Splenectomy / adverse effects*
Wernicke Encephalopathy / diagnosis*,  etiology*,  prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Congenital spinal intradural arachnoid cyst associated with intrathoracic meningocele in a child.
Next Document:  Purification, chemical modification and immunostimulating activity of polysaccharides from Tremella ...