Document Detail


Wernicke-Korsakoff syndrome in monozygotic twins: a biochemical peculiarity.
MedLine Citation:
PMID:  7197998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A pair of monozygotic twins, one suffering from the Wernicke-Korsakoff syndrome, verified at autopsy, and the other healthy, was studied biochemically. The erythrocyte transketolase of each twin showed abnormalities, though these differed in the two individuals. In the healthy twin, the basal transketolase was low, but responded normally to thiamine pyrophosphate (TPP) added in vitro. In the twin with the Wernicke-Korsakoff syndrome the basal level of the enzyme and its response in vitro were normal, but a period of treatment with thiamine tetrahydrofurfuryldisulphide, led to loss of the in vitro response. It is suggested that, initially, an inborn error of metabolism may have been common to both twins.
Authors:
D Leigh; A McBurney; H McIlwain
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  139     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  156-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Amnestic Disorder / drug therapy,  enzymology,  genetics*
Diseases in Twins*
Erythrocytes / enzymology
Female
Fursultiamin / therapeutic use
Humans
Male
Middle Aged
Pregnancy
Thiamine Pyrophosphate / metabolism
Transketolase / blood
Twins, Monozygotic
Wernicke Encephalopathy / drug therapy,  enzymology,  genetics*
Chemical
Reg. No./Substance:
154-87-0/Thiamine Pyrophosphate; 804-30-8/Fursultiamin; EC 2.2.1.1/Transketolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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