| Wernicke-Korsakoff syndrome in monozygotic twins: a biochemical peculiarity. | |
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MedLine Citation:
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PMID: 7197998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pair of monozygotic twins, one suffering from the Wernicke-Korsakoff syndrome, verified at autopsy, and the other healthy, was studied biochemically. The erythrocyte transketolase of each twin showed abnormalities, though these differed in the two individuals. In the healthy twin, the basal transketolase was low, but responded normally to thiamine pyrophosphate (TPP) added in vitro. In the twin with the Wernicke-Korsakoff syndrome the basal level of the enzyme and its response in vitro were normal, but a period of treatment with thiamine tetrahydrofurfuryldisulphide, led to loss of the in vitro response. It is suggested that, initially, an inborn error of metabolism may have been common to both twins. |
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Authors:
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D Leigh; A McBurney; H McIlwain |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 139 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1982-02-22 Completed Date: 1982-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 156-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Amnestic Disorder
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drug therapy,
enzymology,
genetics* Diseases in Twins* Erythrocytes / enzymology Female Fursultiamin / therapeutic use Humans Male Middle Aged Pregnancy Thiamine Pyrophosphate / metabolism Transketolase / blood Twins, Monozygotic Wernicke Encephalopathy / drug therapy, enzymology, genetics* |
| Chemical | |
Reg. No./Substance:
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154-87-0/Thiamine Pyrophosphate; 804-30-8/Fursultiamin; EC 2.2.1.1/Transketolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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