Document Detail

Wernicke-Korsakoff syndrome in monozygotic twins: a biochemical peculiarity.
MedLine Citation:
PMID:  7197998     Owner:  NLM     Status:  MEDLINE    
A pair of monozygotic twins, one suffering from the Wernicke-Korsakoff syndrome, verified at autopsy, and the other healthy, was studied biochemically. The erythrocyte transketolase of each twin showed abnormalities, though these differed in the two individuals. In the healthy twin, the basal transketolase was low, but responded normally to thiamine pyrophosphate (TPP) added in vitro. In the twin with the Wernicke-Korsakoff syndrome the basal level of the enzyme and its response in vitro were normal, but a period of treatment with thiamine tetrahydrofurfuryldisulphide, led to loss of the in vitro response. It is suggested that, initially, an inborn error of metabolism may have been common to both twins.
D Leigh; A McBurney; H McIlwain
Related Documents :
14506648 - Discordancy for maternal floor infarction in dizygotic twin placentas.
16354978 - Triploidy in a growth discordant twin pregnancy after intracytoplasmic sperm injection ...
3134438 - Sonographic detection of monoamniotic twins.
9298158 - The twinning rates and epidemiological characteristics of births in southeast uttar pra...
8792568 - Dynamic changes in the lymphocyte subpopulations of pig uterine lymph nodes.
19178558 - Serum concentration/dose ratio of topiramate during pregnancy.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  139     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  156-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alcohol Amnestic Disorder / drug therapy,  enzymology,  genetics*
Diseases in Twins*
Erythrocytes / enzymology
Fursultiamin / therapeutic use
Middle Aged
Thiamine Pyrophosphate / metabolism
Transketolase / blood
Twins, Monozygotic
Wernicke Encephalopathy / drug therapy,  enzymology,  genetics*
Reg. No./Substance:
154-87-0/Thiamine Pyrophosphate; 804-30-8/Fursultiamin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Transbilayer distribution in small unilamellar phosphatidylglycerol-phosphatidylcholine vesicles.
Next Document:  Further evidence for selective antagonism of taurine by 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadia...