| Well-quantified tuberculosis exposure is a reliable surrogate measure of tuberculosis infection. | |
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MedLine Citation:
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PMID: 22692027 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SETTING: Cape Town, South Africa.OBJECTIVE: To develop a standardized, reliable measure of household tuberculosis (TB) exposure that considers child-specific risk factors.DESIGN: We assessed TB exposure in 536 children. Children were considered Mycobacterium tuberculosis infected if two of three tests of infection were positive. Principal component analysis identified a discrete set of components that collectively described exposure and contributed to a composite contact score. Logistic regression assessed the odds of having M. tuberculosis infection given increasing contact score while controlling for age and past TB treatment.RESULTS: Four components described 68% of data variance: 1) maternal TB and sleep proximity, 2) index case infectivity, 3) duration of exposure, and 4) exposure to multiple index cases. Components were derived from 10 binary questions that contributed to a contact score (range 1-10, median 5, 25th-75th interquartile range [IQR] 4-7). Among children aged 3 months to 6 years with household exposure, the odds of being M. tuberculosis-infected increased by 74% (OR 1.74, 95%CI 1.42-2.12) with each 1-point increase in the contact score.CONCLUSIONS: Well-quantified TB exposure is a good surrogate measure of M. tuberculosis infection in child household contacts in a high-burden setting, and could guide targeted preventive treatment in children at highest risk of M. tuberculosis infection. |
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Authors:
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A M Mandalakas; H L Kirchner; C Lombard; G Walzl; H M S Grewal; R P Gie; A C Hesseling |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-11 |
Journal Detail:
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Title: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: - ISSN: 1815-7920 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706389 Medline TA: Int J Tuberc Lung Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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