| Well-differentiated endocrine tumours of the middle ear and of the hindgut have immunocytochemical and ultrastructural features in common. | |
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MedLine Citation:
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PMID: 7599794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunocytochemical analysis of two cases of well-differentiated endocrine tumours (carcinoids) of the middle ear revealed predominant cell populations producing pancreatic polypeptide (PP)-related peptides, glucagon-related peptides, and serotonin (the latter only in one case). In consecutive sections PP- and glucagon-related immunoreactivities mainly colocalized in the same tumour cells. Ultrastructurally tumour cells were characterized by medium-sized to large granules of moderate to high density, on which PP and glicentin were localized by the immunogold technique. No amphicrine cells were found. These features are consistent with those of similar tumours in the rectal mucosa that are mainly composed of L cells coexpressing both PP-related and glucagon-related peptides. Additional tumour antigens of hindgut type detected immunohistochemically were prostatic acid phosphatase and CAR-5 mucin. Expression of the CAR-5 antigen was also found in samples of normal middle ear mucosa, in which endocrine cells have not been identified. In case 1 peritumoral mucosal invaginations showed a proliferation of endocrine cells identical immunophenotypically to tumour cells, possibly representing a precursor lesion. It is concluded that well-differentiated endocrine tumours of the middle ear are a distinct pathological entity characterized by multiple hormone production, typically involving three classes of hormones (pancreatic polypeptide-related peptides, glucagon-related peptides, and serotonin) of the hindgut endocrine system. |
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Authors:
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C Azzoni; M Bonato; T D'Adda; L Usellini; F Piazza; A Gandolfi; C Bordi; C Capella |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 426 ISSN: 0945-6317 ISO Abbreviation: Virchows Arch. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-08-09 Completed Date: 1995-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: GERMANY |
Other Details:
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Languages: eng Pagination: 411-8 Citation Subset: IM |
Affiliation:
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Institute of Anatomic Patology, University of Parma, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carcinoid Tumor / metabolism, ultrastructure* Ear Neoplasms / metabolism, ultrastructure* Ear, Middle* Female Glucagon / analysis Humans Intestinal Neoplasms / metabolism, ultrastructure* Male Middle Aged Pancreatic Polypeptide / analysis Serotonin / analysis |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 59763-91-6/Pancreatic Polypeptide; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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