Document Detail

Well-being and cerebral oxygen saturation during acute heart failure in humans.
MedLine Citation:
PMID:  10735984     Owner:  NLM     Status:  MEDLINE    
Cerebral symptoms and near-infrared spectrophotometry-determined cerebral oxygen saturation (ScO2) were followed in patients treated for normotensive acute congestive heart failure. The reproducibility and normal range for ScO2 were established from 39 resting subjects without cardio-respiratory disease: the ScO2 ranged from 55 to 78% with a coefficient of variation for triple determination of 6%. Patients rated cerebral symptoms on a scale with end-points of 0 (best) and 10 (worst). In eight patients with acute heart failure, arterial oxygen tension increased during decongestive treatment, from 9.1 (4.9-10) to 10.4 kPa (7.3-17); median with range, as did arterial oxygen saturation, from 94 (48-97) to 97% (87-99) (P<0.02), whereas the mean arterial pressure, heart rate and arterial carbon dioxide tension remained unchanged. The cerebral symptom score improved from 8 (3-10) to 1 (1-9) and the ScO2 increased from 34 (20-58) to 50% (19-91) (P<0.02). A ninth patient presented with a silent but massive myocardial infarction: she was cerebrally obtunded with a ScO2 of 18% and soon died. In patients with normotensive acute heart failure and cerebral symptoms, cerebral oxygen saturation is low, and during successful treatment ScO2 increases with the well-being of the patient.
P L Madsen; H B Nielsen; P Christiansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  20     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-24     Completed Date:  2000-04-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
Department of Internal Medicine, Naestved Community Hospital, Denmark.
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MeSH Terms
Acute Disease
Aged, 80 and over
Blood Pressure / physiology
Cerebrovascular Circulation / physiology
Heart Failure / diagnosis,  physiopathology*
Hypotension / diagnosis,  physiopathology
Middle Aged
Oxygen / blood*
Spectroscopy, Near-Infrared
Tilt-Table Test
Reg. No./Substance:

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