| Well-Defined Homopolypeptides, Copolypeptides and Hybrids of Poly(L-proline). | |
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MedLine Citation:
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PMID: 21568310 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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L-proline is the only, out of twenty essential, amino acid which contains a cyclized substituted α-amino group (is formally an imino acid), which restricts its conformational shape. The synthesis of well-defined homo- and copolymers of L-proline has been plagued either by the low purity of the monomer, or the inability of most initiating species to polymerize the corresponding N-carboxy anhydride (NCA), since they require a hydrogen on the 3-N position of the 5-member ring of the NCA, which is missing. Herein, highly pure L-proline NCA was synthesized by using the Boc-protected, rather than the free amino acid. The protection of the amine group as well as the efficient purification method utilized, resulted in the synthesis of highly pure L-proline NCA. The high purity of the monomer and the use of an amino initiator, which does not require the presence of the 3-N hydrogen, led for the first time, to well-defined poly(L-proline) (PLP) homopolymers, poly(ethylene oxide)-b-poly(L-proline) and poly(L-proline)-b-poly(ethylene oxide)-b-poly(L-proline) hybrids, along with poly(γ-benzyl-L-glutamate)-b-poly(L-proline) and poly(Boc-L-lysine)-b-poly(L-proline) copolypeptides. The combined characterization (NMR, FTIR and MS) results for the L-proline NCA revealed its high purity. In addition all synthesized polymers exhibit high molecular and compositional homogeneity. |
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Authors:
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Manos Gkikas; Hermis Iatrou; Nikolaos S Thomaidis; Paschalis Alexandridis; Nikos Hadjichristidis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-13 |
Journal Detail:
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Title: Biomacromolecules Volume: - ISSN: 1526-4602 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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