Document Detail


Welding characteristics of different albumin species with and without fatty acids.
MedLine Citation:
PMID:  10918297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Albumin solders from different species have been used for laser tissue welding without a complete understanding of possible differences between them. The breaking strength of four different species of serum albumin (human, bovine, porcine, and canine), both fatty acid containing (FAC) and fatty acid free (FAF), was determined to evaluate the welding ability of each type of albumin. STUYDY DESIGN/MATERIALS AND METHODS: Acute breaking strengths were determined on canine small bowel by using 50% albumin (FAF and FAC) from human, bovine (BSA), porcine, and canine species. RESULTS: BSA-FAC and BSA-FAF had a significantly higher (P < 0.05) breaking strength than all other groups; furthermore, BSA-FAC was significantly higher (P < 0.05) than BSA-FAF. There was no significant difference in breaking strength when FAF albumin was compared with FAC albumin from humans, pigs, or dogs. CONCLUSION: These experimental results show that species-specific and fatty acid-specific differences exist when these albumin solders are used for laser tissue welding. This finding suggests that modifications in albumin could be used to improve results through decreased thermal damage and increased weld strength.
Authors:
C B Bleustein; D Felsen; D P Poppas
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  27     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  2000  
Date Detail:
Created Date:  2000-09-27     Completed Date:  2000-09-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  82-6     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Affiliation:
Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Department of Urology, New York-Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Fatty Acids*
Hot Temperature
Intestine, Small / injuries,  surgery*
Laser Coagulation / methods*
Protein Denaturation
Serum Albumin / chemistry*,  therapeutic use
Serum Albumin, Bovine / therapeutic use
Species Specificity
Tensile Strength
Tissue Adhesives / chemistry*,  therapeutic use*
Wound Healing*
Wounds and Injuries / physiopathology,  surgery*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Serum Albumin; 0/Serum Albumin, Bovine; 0/Tissue Adhesives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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