Document Detail


Welder's pneumoconiosis: diagnostic usefulness of high-resolution computed tomography and ferritin determinations in bronchoalveolar lavage fluid.
MedLine Citation:
PMID:  12521198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We assessed the usefulness of high-resolution computed tomography (HRCT) and ferritin determinations in bronchoalveolar lavage (BAL) fluid for diagnosis of welder's pneumoconiosis. PATIENTS AND METHODS: We investigated 11 patients with welder's pneumoconiosis who were 34 to 67 years old and had been welding for 17 to 45 years. Ten patients were current smokers. We performed chest radiography and HRCT, and measured serum ferritin on all 11 patients. We obtained BAL fluid in 9 cases and transbronchial lung biopsy (TBLB) specimens in 7. Ferritin concentrations in BAL fluid were compared with those in welders without pneumoconiosis and other pneumoconiosis cases. RESULTS: HRCT revealed small centrilobular nodules in 9 cases, mild fibrotic changes in 3, and emphysematous changes in 3. Serum ferritin concentrations were elevated (>240 ng/ml) in 10 cases. Ferritin concentrations in BAL fluid were higher in welder's pneumoconiosis than in the occupational control group. CONCLUSION: In welder's pneumoconiosis, small centrilobular nodules are frequently seen on HRCT, and ferritin shows elevations in serum and/or BAL fluid. Such ferritin determinations are of value in diagnosis.
Authors:
Chiharu Yoshii; Tsuneo Matsuyama; Akiko Takazawa; Toshiro Ito; Kazuhiro Yatera; Toshinari Hayashi; Tomotoshi Imanaga; Masamitsu Kido
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  41     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-10     Completed Date:  2003-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1111-7     Citation Subset:  IM    
Affiliation:
Department of Respiratory Disease, University of Occupational and Environmental Health, Kitakyushu.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biopsy
Bronchoalveolar Lavage Fluid / chemistry*
Ferritins / analysis*
Humans
Lung / pathology
Male
Middle Aged
Siderosis / diagnosis*
Smoking
Tomography, X-Ray Computed / methods*
Welding*
Chemical
Reg. No./Substance:
9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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