| Weight reduction and long-term maintenance after 18 months treatment with orlistat for obesity. | |
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MedLine Citation:
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PMID: 12704403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effect of orlistat on weight reduction and the long-term maintenance of this weight loss when associated with a continuous mildly reduced energy diet. DESIGN: A multicenter, 18-month, double-blind study conducted in 81 hospital centers. Patients were randomized to orlistat 120 mg or placebo three times daily in conjunction with a mildly reduced-energy diet maintained throughout the study. SUBJECTS: In total, 696 otherwise healthy, overweight patients aged 18-65 y (BMI >or=28 kg/m(2)) were randomized to treatment with orlistat (n=346) or placebo (n=350). MEASUREMENTS: Body weight, anthropometry, lipid and glycemic control parameters and blood pressure. RESULTS: After 18 months, patients treated with orlistat lost significantly more body weight compared with placebo (-6.5+/-0.8 vs -3.0+/-0.8%; P=0.0005). After 12 months, 32.9% of orlistat vs 24.5% of placebo patients lost >or=10% of their initial weight (P=0.04). A significantly greater number of patients receiving orlistat treatment maintained this >or=10% weight loss compared to those receiving placebo (28.1 vs 13.8%; P<0.0001). Compared with placebo, orlistat was associated with a greater decrease in fasting blood glucose (-0.86+/-0.12 vs -0.29+/-0.18 mmol/l; P<0.05) and LDL-cholesterol (-13.0+/-1.3 vs -7.0+/-1.3%; P<0.001). CONCLUSION: A clinically meaningful reduction in body weight and the maintenance of this weight loss is achievable with orlistat treatment and dietary restriction over a period of 18 months. This weight loss resulted in an improvement in risk factors for coronary heart disease. |
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Authors:
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M Krempf; J-P Louvet; H Allanic; T Miloradovich; J-M Joubert; J-R Attali |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity Volume: 27 ISSN: 0307-0565 ISO Abbreviation: Int. J. Obes. Relat. Metab. Disord. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-21 Completed Date: 2003-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9313169 Medline TA: Int J Obes Relat Metab Disord Country: England |
Other Details:
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Languages: eng Pagination: 591-7 Citation Subset: IM |
Affiliation:
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CHU Hôtel-Dieu, Service d'Endocrinologie-Nutrition, Nantes, France. mkemppf@sante.univ-nantes.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anti-Obesity Agents / adverse effects, therapeutic use* Double-Blind Method Energy Intake Female Gastrointestinal Diseases / chemically induced Humans Lactones / adverse effects, therapeutic use* Long-Term Care Male Middle Aged Obesity / drug therapy* Risk Factors Treatment Outcome Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Lactones; 96829-58-2/orlistat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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