| Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase. | |
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MedLine Citation:
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PMID: 14998716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fatty acid synthase (EC 2. 3. 1. 85, abbr. FAS) is reported as a potential new therapeutic target for the treatment of obesity. Thirty one Chinese medicinal herbs used in weight reducing prescriptions of Traditional Chinese Medicine (TCM) were investigated for FAS inhibition. It was found that 17 of these herbs exhibited FAS inhibitor activity, and 9 were highly potent FAS inhibitors. The inhibitory potencies of the active components of tuber fleeceflower root, parasitic loranthus, green tea leaf and ginkgo leaf were similar to or greater than cerulenin and C75. The first three of these four herbs significantly reduced body weight of rats upon their oral incubation. Moreover, tuber fleeceflower root and parasitic loranthus significantly reduced food intake in rats. These results indicate that many of weight reducing herbs used in TCM do so by inhibiting FAS. They also hold promise for the development of new nontoxic and low cost weight reducing substances from these herbs. |
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Authors:
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Wei-Xi Tian; Li-Chun Li; Xiao-Dong Wu; Chuan-Chu Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 74 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-04 Completed Date: 2004-04-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 2389-99 Citation Subset: IM |
Affiliation:
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Department of Biology, the Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China. tianweixi@gscas.ac.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens Drugs, Chinese Herbal / metabolism, pharmacology*, therapeutic use Eating Enzyme Inhibitors / metabolism, pharmacology*, therapeutic use Fatty Acid Synthetase Complex / antagonists & inhibitors*, metabolism Female Humans Obesity / drug therapy Phytotherapy Random Allocation Rats Weight Loss* |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/Enzyme Inhibitors; EC 6.-/Fatty Acid Synthetase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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