| Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. | |
| | |
MedLine Citation:
|
PMID: 20679559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Previous studies comparing low-carbohydrate and low-fat diets have not included a comprehensive behavioral treatment, resulting in suboptimal weight loss. OBJECTIVE: To evaluate the effects of 2-year treatment with a low-carbohydrate or low-fat diet, each of which was combined with a comprehensive lifestyle modification program. DESIGN: Randomized parallel-group trial. (ClinicalTrials.gov registration number: NCT00143936) SETTING: 3 academic medical centers. PATIENTS: 307 participants with a mean age of 45.5 years (SD, 9.7 years) and mean body mass index of 36.1 kg/m(2) (SD, 3.5 kg/m(2)). INTERVENTION: A low-carbohydrate diet, which consisted of limited carbohydrate intake (20 g/d for 3 months) in the form of low-glycemic index vegetables with unrestricted consumption of fat and protein. After 3 months, participants in the low-carbohydrate diet group increased their carbohydrate intake (5 g/d per wk) until a stable and desired weight was achieved. A low-fat diet consisted of limited energy intake (1200 to 1800 kcal/d; <or=30% calories from fat). Both diets were combined with comprehensive behavioral treatment. MEASUREMENTS: Weight at 2 years was the primary outcome. Secondary measures included weight at 3, 6, and 12 months and serum lipid concentrations, blood pressure, urinary ketones, symptoms, bone mineral density, and body composition throughout the study. RESULTS: Weight loss was approximately 11 kg (11%) at 1 year and 7 kg (7%) at 2 years. There were no differences in weight, body composition, or bone mineral density between the groups at any time point. During the first 6 months, the low-carbohydrate diet group had greater reductions in diastolic blood pressure, triglyceride levels, and very-low-density lipoprotein cholesterol levels, lesser reductions in low-density lipoprotein cholesterol levels, and more adverse symptoms than did the low-fat diet group. The low-carbohydrate diet group had greater increases in high-density lipoprotein cholesterol levels at all time points, approximating a 23% increase at 2 years. LIMITATION: Intensive behavioral treatment was provided, patients with dyslipidemia and diabetes were excluded, and attrition at 2 years was high. CONCLUSION: Successful weight loss can be achieved with either a low-fat or low-carbohydrate diet when coupled with behavioral treatment. A low-carbohydrate diet is associated with favorable changes in cardiovascular disease risk factors at 2 years. PRIMARY FUNDING SOURCE: National Institutes of Health. |
| | |
Authors:
|
Gary D Foster; Holly R Wyatt; James O Hill; Angela P Makris; Diane L Rosenbaum; Carrie Brill; Richard I Stein; B Selma Mohammed; Bernard Miller; Daniel J Rader; Babette Zemel; Thomas A Wadden; Thomas Tenhave; Craig W Newcomb; Samuel Klein |
Related Documents
:
|
1129769 - Sex-difference in the response to different kinds of dietary carbohydrates in rats. 2194509 - Effect of low fat-high carbohydrate diets in hypertensive patients with non-insulin-dep... 8151479 - Use of high-fat formula for premature infants with bronchopulmonary dysplasia: metaboli... 9361729 - Food intake and weight of lactating rats maintained on different protein-calorie diets,... 17539869 - Dietary fat and appetite: similarities and differences in the satiating effect of meals... 17824299 - Low carbohydrate ketogenic diet enhances cardiac tolerance to global ischaemia. 3056429 - Effects of lovastatin alone and in combination with cholestyramine on serum lipids and ... 9594389 - The effects of disease, management, and nutrition on average daily gain of dairy heifer... 12524469 - Leptin-induced changes in body composition in high fat-fed mice. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Annals of internal medicine Volume: 153 ISSN: 1539-3704 ISO Abbreviation: Ann. Intern. Med. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-03 Completed Date: 2010-08-13 Revised Date: 2010-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: United States |
Other Details:
|
Languages: eng Pagination: 147-57 Citation Subset: AIM; IM |
Affiliation:
|
Center for Obesity Research and Education, Temple University, Philadelphia, Pennsylvania 19140, USA. gfoster@temple.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00143936 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Behavior Therapy* Blood Pressure Body Composition Bone Density Diet, Carbohydrate-Restricted* Diet, Fat-Restricted* Exercise Therapy Female Humans Ketone Bodies / urine Lipoproteins / blood Male Middle Aged Overweight / diet therapy, metabolism, therapy* Treatment Outcome Weight Loss Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
DK 56341/DK/NIDDK NIH HHS; R01 AT001103-01/AT/NCCAM NIH HHS; R01 AT1103/AT/NCCAM NIH HHS; UL1 RR000051/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1RR024134/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Ketone Bodies; 0/Lipoproteins |
| Comments/Corrections | |
Comment In:
|
Ann Intern Med. 2010 Aug 3;153(3):I35
[PMID:
20679555
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nonoptimal Lipids Commonly Present in Young Adults and Coronary Calcium Later in Life: The CARDIA (C...
Next Document: Outcome reporting among drug trials registered in ClinicalTrials.gov.