Document Detail

Weight loss: a neglected intervention in the management of chronic kidney disease.
MedLine Citation:
PMID:  20827193     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Obesity is being increasingly implicated as an independent risk factor for the development of chronic kidney disease (CKD), raising the question whether reversing obesity can be utilized as a mainstay or an adjunct therapy for CKD and possibly for its prevention. The purpose of this review is to examine the impact of treatment of obesity on renal outcomes.
RECENT FINDINGS: Many observations have pointed to improvement in renal parameters following weight loss. In fact, both surgical and nonsurgical approaches appear to be effective at reducing blood pressure and proteinuria. Weight loss has also been shown to lower glomerular filtration rate (GFR) in obese patients, not an insignificant benefit considering that intra-glomerular hypertension and the subsequent hyperfiltration in the setting of obesity might be a main driver for the development of CKD.
SUMMARY: Urinary protein excretion, blood pressure, and GFR improve with surgical and nonsurgical weight loss interventions. Whether improvements in these surrogate outcomes after weight loss actually translate into a reduction in the risk of CKD or amelioration in the rate of progression of established CKD is yet to be determined.
Hassan N Ibrahim; Marc L Weber
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  19     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2011-02-01     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  534-8     Citation Subset:  IM    
Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, Minnesota 55414, USA.
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MeSH Terms
Blood Pressure
Chronic Disease
Glomerular Filtration Rate
Kidney Diseases / etiology,  physiopathology,  prevention & control*
Obesity / complications,  physiopathology,  therapy*
Proteinuria / etiology,  prevention & control
Risk Assessment
Risk Factors
Treatment Outcome
Weight Loss*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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