| Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training. | |
| | |
MedLine Citation:
|
PMID: 22392834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We reported that weight loss induces bone loss which is prevented by exercise training; however, the mechanism for this observation remains unclear. Sclerostin, an inhibitor of bone formation, has been found to increase in states of unloading and may mediate the changes in bone metabolism associated with weight loss and exercise. The objective of the study was to determine the effect of lifestyle intervention in obese older adults on sclerostin levels, and on hip geometry parameters. A total of 107 obese (body mass index [BMI] ≥ 30 kg/m(2)) older (≥65 years) adults were randomly assigned to control, diet, exercise, and combined diet-exercise for 1 year. Sclerostin levels were measured by ELISA at baseline, 6 months, and 12 months, while hip geometry parameters were obtained from bone mineral density (BMD) images done by dual-energy X-ray absorptiometry using hip structure analysis at baseline and 12 months. Both the diet and diet-exercise groups had significant decreases in body weight (-9.6% and -9.4%, respectively), whereas weight was stable in the exercise and control groups. Sclerostin levels increased significantly and progressively in the diet group (6.6% ± 1.7% and 10.5% ± 1.9% at 6 and 12 months, respectively, all p < 0.05), whereas they were unchanged in the other groups; in particular, they were stable in the diet-exercise group (0.7% ± 1.6% and 0.4% ± 1.7% at 6 and 12 months, respectively, all p = 0.05). Hip geometry parameters showed significant decreases in cross-sectional area, cortical thickness, and BMD; and increases in buckling ratio at the narrow neck, intertrochanter, and femoral shaft. These negative changes on bone geometry were not observed in the diet-exercise group. Significant correlations between changes in sclerostin and changes in certain hip geometry parameters were also observed (p < 0.05). In conclusion, the increase in sclerostin levels with weight loss that was prevented by exercise may partly mediate the negative effects of weight loss on bone metabolism and the osteoprotective effect of exercise training. |
| | |
Authors:
|
Reina Armamento-Villareal; Corinn Sadler; Nicola Napoli; Krupa Shah; Suresh Chode; David R Sinacore; Clifford Qualls; Dennis T Villareal |
Related Documents
:
|
12218734 - Relations of adiposity and effects of training on the left ventricle in obese youths. 19253184 - Left ventricular diastolic function assessed with cardiovascular magnetic resonance ima... 16004904 - Relationship between echocardiographic and aerobic capacity parameters in distance runn... 22760814 - Does physical exercise reduce excessive daytime sleepiness by improving inflammatory pr... 8184964 - Role of endothelium-derived relaxing factor in hindlimb reactive and active hyperemia i... 9083284 - Effect of amino acid administration on uremic muscle metabolism: a 31p-spectroscopy study. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Volume: 27 ISSN: 1523-4681 ISO Abbreviation: J. Bone Miner. Res. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-05-28 Completed Date: 2012-09-27 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 8610640 Medline TA: J Bone Miner Res Country: United States |
Other Details:
|
Languages: eng Pagination: 1215-21 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 American Society for Bone and Mineral Research. |
Affiliation:
|
Division of Geriatrics, University of New Mexico School of Medicine, Albuquerque, NM, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorptiometry, Photon Aged Bone Density Bone Morphogenetic Proteins / blood*, metabolism Enzyme-Linked Immunosorbent Assay Exercise / physiology* Female Genetic Markers Hip / pathology* Humans Male Obesity* Osteoporosis / prevention & control Up-Regulation Weight Loss / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
DK20579/DK/NIDDK NIH HHS; P30 DK056341-05/DK/NIDDK NIH HHS; P30-DK56341/DK/NIDDK NIH HHS; P60 DK020579-35/DK/NIDDK NIH HHS; R01 AG025501-05/AG/NIA NIH HHS; R01 AG031176/AG/NIA NIH HHS; R01 AG031176-02/AG/NIA NIH HHS; R01-AG025501/AG/NIA NIH HHS; R01-AG031176/AG/NIA NIH HHS; UL1 RR024992-04/RR/NCRR NIH HHS; UL1 TR000041/TR/NCATS NIH HHS; UL1-RR024992/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Bone Morphogenetic Proteins; 0/Genetic Markers; 0/SOST protein, human |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Liraglutide-induced acute kidney injury.
Next Document: Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and afte...