Document Detail

Weight limitations for weekly urea clearances using various exchange volumes in continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  7948239     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To calculate the relationships of weekly KT/V urea to standard body weight with different exchange volumes (2, 2.5, or 3 L) for continuous ambulatory peritoneal dialysis (CAPD) in functionally anephric patients and to display the results in graphic form. DESIGN: Theoretical calculations using previously measured 24-hour dialysate/plasma urea values in 77 CAPD patients and other defined components of weekly KT/V urea. SETTING: Measurements and calculations in theoretical patients doing standard CAPD with four daily exchanges. PATIENTS: Theoretical functionally anephric patients on standard CAPD as above. INTERVENTIONS: Theoretical calculations based on instillation of 2-, 2.5-, and 3-L exchange volumes. MAIN OUTCOME MEASURES: Weekly urea clearances normalized to total body water (weekly KT/V urea). The values using different exchange volumes were related to standard body weight. RESULTS: Although a minimum recommended weekly KT/V urea target is arbitrary, the results illustrate the range of flexibility of CAPD relative to KT/V urea values with variations in exchange volume. The standard weights above which anephric patients on CAPD using four exchanges per day with 2-, 2.5-, and 3-L exchanges cannot reach a weekly KT/V urea target of 1.7, have been identified. The range of weekly KT/V urea levels possible with different exchange-volume programs has been graphically illustrated. CONCLUSIONS: Weights above which a weekly KT/V urea of 1.7 cannot be reached in functionally anephric patients are 64, 77.6, and 91 kg for CAPD using 2-, 2.5-, and 3-L exchanges, respectively.
K D Nolph; R A Jensen; R Khanna; Z J Twardowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  14     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  261-4     Citation Subset:  IM    
Department of Internal Medicine, University of Missouri Health Sciences, Center, Columbia 65212.
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MeSH Terms
Body Weight*
Dialysis Solutions / administration & dosage*,  chemistry
Kidney Failure, Chronic / metabolism,  therapy
Peritoneal Dialysis, Continuous Ambulatory*
Urea / analysis*,  metabolism
Reg. No./Substance:
0/Dialysis Solutions; 57-13-6/Urea

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