Document Detail

Weight gain and hormone replacement therapy: are women's fears justified?
MedLine Citation:
PMID:  10759058     Owner:  NLM     Status:  MEDLINE    
Fear of weight gain is one of the main factors contributing to the poor compliance seen with hormone replacement therapy (HRT). Although an increase in weight can be a result of rehydration, (which in turn may alleviate some of the effects of skin ageing), many women consider weight gain to be cosmetically unacceptable. Moreover, excess body weight or certain patterns of body fat distribution can lead to health problems such as cardiovascular disease and breast cancer. The menopause is associated with a decrease in the resting metabolic rate that reduces the utilisation of calories and hence increases body weight. A number of studies have shown that weight gain is greatest in the peri-menopausal years. There also appears to be a redistribution of fat mass at the time of the menopause, with an increase in the waist-to-hip ratio. Although it is a common belief that HRT inevitably causes weight gain, available evidence suggests that this is not true. Indeed, some HRT regimens, such as continuous 17beta-oestradiol 2 mg/day combined with sequential dydrogesterone 10 mg/day for 14 days/cycle (Femoston), may actually help to prevent an increase in body fat mass and fat redistribution. Informing women about the effects of the menopause on body weight/fat distribution and the potential beneficial effects of some HRT regimens should help to improve HRT compliance.
I van Seumeren
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Maturitas     Volume:  34 Suppl 1     ISSN:  0378-5122     ISO Abbreviation:  Maturitas     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-04-28     Completed Date:  2000-04-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  S3-8     Citation Subset:  IM    
University Hospital Utrecht, The Netherlands.
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MeSH Terms
Dydrogesterone / pharmacology,  therapeutic use
Estradiol / pharmacology,  therapeutic use
Fat Body
Hormone Replacement Therapy / adverse effects*
Longitudinal Studies
Menopause / physiology*,  psychology*
Middle Aged
Patient Compliance
Risk Factors
Weight Gain / drug effects*
Reg. No./Substance:
152-62-5/Dydrogesterone; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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