| Weight gain during insulin therapy in patients with type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 15315867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with diabetes, the benefits of tight glycemic control are unequivocal--delayed onset and progression of complications such as retinopathy, nephropathy, and neuropathy. However, intensive therapy with insulin and some oral antidiabetic agents come at the price of weight gain, a condition that can prevent attainment of tight glycemic goals and probably limits success of treatment. Insulin-related weight gain has been attributed to anabolic effects of insulin, appetite increases, and reduction of glycosuria. Use of metformin in combination with insulin is commonly recommended as a way to limit weight gain in patients with type 2 diabetes, and other new oral therapies and insulin analogs may also provide weight-control advantages. Lifestyle interventions (patient education about diet and exercise) promote weight loss in the short-term, but have not sustained weight control over long-term intervals. For lasting weight control, such interventions may need to continue throughout the course of treatment. Likewise, weight-loss agents, such as sibutramine and orlistat promote short-term weight loss, but no follow-up studies have yet demonstrated that this loss can be maintained for 5 years or longer. Bariatric surgery is the only treatment recognized to have lasting effects on weight control, but its use is limited at present to those who are morbidly obese. |
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Authors:
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Simon Heller |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 65 Suppl 1 ISSN: 0168-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-18 Completed Date: 2005-02-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: S23-7 Citation Subset: IM |
Affiliation:
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University of Sheffield, Section of Medicine, Clinical Sciences Centre, Sheffield S102TN, UK. s.heller@sheffield.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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metabolism Diabetes Mellitus, Type 2 / drug therapy*, physiopathology*, rehabilitation Exercise Humans Hypoglycemic Agents / therapeutic use Insulin / therapeutic use* Obesity / prevention & control Patient Education as Topic* Weight Gain / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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