| Weight gain associated with valproate in childhood. | |
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MedLine Citation:
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PMID: 10913727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Weight gain is a common side effect of valproate treatment. Several mechanisms have been suggested for its pathophysiology; of these, impairment of beta-oxidation of fatty acids and increased insulin secretion have been supported by clinical studies. To investigate whether changes in carnitine and insulin levels had a role in the weight gain occurring with valproate treatment in children, 20 patients with epilepsy were randomly assigned to receive either carnitine or placebo supplementation in addition to valproate. After a follow-up period of 3 months, weight gain was observed in both groups. The mean insulin concentration and insulin/glucose ratios increased. Weight gain did not correlate with carnitine levels. These results suggest that weight gain during valproate treatment is not related to a decrease in carnitine levels. However, an increase in insulin levels together with a decrease in glucose levels may cause weight gain, possibly by stimulating appetite. |
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Authors:
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E Demir; S Aysun |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Pediatric neurology Volume: 22 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-08-23 Completed Date: 2000-08-23 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 361-4 Citation Subset: IM |
Affiliation:
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Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anticonvulsants / adverse effects*, therapeutic use Blood Glucose / drug effects Carnitine / blood, therapeutic use* Child Child, Preschool Drug Therapy, Combination Epilepsy, Generalized / blood, complications, drug therapy* Female Humans Insulin / blood, metabolism Male Treatment Outcome Valproic Acid / adverse effects*, therapeutic use Weight Gain / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Blood Glucose; 11061-68-0/Insulin; 541-15-1/Carnitine; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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