Document Detail


Weight gain is associated with reduced striatal response to palatable food.
MedLine Citation:
PMID:  20881128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors and show less striatal response to palatable food intake. Low striatal response to food intake predicts future weight gain in those at genetic risk for reduced signaling of dopamine-based reward circuitry. Yet animal studies indicate that intake of palatable food results in downregulation of D2 receptors, reduced D2 sensitivity, and decreased reward sensitivity, implying that overeating may contribute to reduced striatal responsivity. Thus, we tested whether overeating leads to reduced striatal responsivity to palatable food intake in humans using repeated-measures functional magnetic resonance imaging. Results indicated that women who gained weight over a 6 month period showed a reduction in striatal response to palatable food consumption relative to weight-stable women. Collectively, results suggest that low sensitivity of reward circuitry increases risk for overeating and that this overeating may further attenuate responsivity of reward circuitry in a feedforward process.
Authors:
Eric Stice; Sonja Yokum; Kenneth Blum; Cara Bohon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2010-10-25     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13105-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Appetite Regulation / physiology*
Appetitive Behavior / physiology
Brain Mapping / methods
Corpus Striatum / anatomy & histology,  physiology*
Female
Humans
Hyperphagia / physiopathology*,  psychology
Magnetic Resonance Imaging
Neural Inhibition / physiology*
Neuropsychological Tests
Obesity / physiopathology*,  psychology
Prospective Studies
Reward
Weight Gain / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
DK080760/DK/NIDDK NIH HHS; R01 DK080760/DK/NIDDK NIH HHS; R01 DK080760-01A2/DK/NIDDK NIH HHS; R01 MH064560/MH/NIMH NIH HHS; R01 MH064560-01A1/MH/NIMH NIH HHS; R1MH64560A/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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