Document Detail

Weight gain is associated with reduced striatal response to palatable food.
MedLine Citation:
PMID:  20881128     Owner:  NLM     Status:  MEDLINE    
Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors and show less striatal response to palatable food intake. Low striatal response to food intake predicts future weight gain in those at genetic risk for reduced signaling of dopamine-based reward circuitry. Yet animal studies indicate that intake of palatable food results in downregulation of D2 receptors, reduced D2 sensitivity, and decreased reward sensitivity, implying that overeating may contribute to reduced striatal responsivity. Thus, we tested whether overeating leads to reduced striatal responsivity to palatable food intake in humans using repeated-measures functional magnetic resonance imaging. Results indicated that women who gained weight over a 6 month period showed a reduction in striatal response to palatable food consumption relative to weight-stable women. Collectively, results suggest that low sensitivity of reward circuitry increases risk for overeating and that this overeating may further attenuate responsivity of reward circuitry in a feedforward process.
Eric Stice; Sonja Yokum; Kenneth Blum; Cara Bohon
Related Documents :
23064178 - Novel bio-active lipid nanocarriers for the stabilization and sustained release of sito...
14739028 - Trypanosoma cruzi transmission in a captive primate unit, rio de janeiro, brazil.
9528118 - Hand use and gestural communication in chimpanzees (pan troglodytes).
20680018 - Taste, olfactory and food texture reward processing in the brain and obesity.
24005858 - Visual illusions and plate design: the effects of plate rim widths and rim coloring on ...
17370278 - Compostability of bioplastic packaging materials: an overview.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2010-10-25     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13105-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Appetite Regulation / physiology*
Appetitive Behavior / physiology
Brain Mapping / methods
Corpus Striatum / anatomy & histology,  physiology*
Hyperphagia / physiopathology*,  psychology
Magnetic Resonance Imaging
Neural Inhibition / physiology*
Neuropsychological Tests
Obesity / physiopathology*,  psychology
Prospective Studies
Weight Gain / physiology*
Young Adult
Grant Support
DK080760/DK/NIDDK NIH HHS; R01 DK080760/DK/NIDDK NIH HHS; R01 DK080760-01A2/DK/NIDDK NIH HHS; R01 MH064560/MH/NIMH NIH HHS; R01 MH064560-01A1/MH/NIMH NIH HHS; R01 MH064560-02/MH/NIMH NIH HHS; R01 MH064560-02S1/MH/NIMH NIH HHS; R01 MH064560-03/MH/NIMH NIH HHS; R01 MH064560-04/MH/NIMH NIH HHS; R01 MH064560-04S1/MH/NIMH NIH HHS; R01 MH064560-05/MH/NIMH NIH HHS; R1MH64560A/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The architecture of reward value coding in the human orbitofrontal cortex.
Next Document:  Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement o...