| Weight gain is associated with reduced striatal response to palatable food. | |
| | |
MedLine Citation:
|
PMID: 20881128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors and show less striatal response to palatable food intake. Low striatal response to food intake predicts future weight gain in those at genetic risk for reduced signaling of dopamine-based reward circuitry. Yet animal studies indicate that intake of palatable food results in downregulation of D2 receptors, reduced D2 sensitivity, and decreased reward sensitivity, implying that overeating may contribute to reduced striatal responsivity. Thus, we tested whether overeating leads to reduced striatal responsivity to palatable food intake in humans using repeated-measures functional magnetic resonance imaging. Results indicated that women who gained weight over a 6 month period showed a reduction in striatal response to palatable food consumption relative to weight-stable women. Collectively, results suggest that low sensitivity of reward circuitry increases risk for overeating and that this overeating may further attenuate responsivity of reward circuitry in a feedforward process. |
| | |
Authors:
|
Eric Stice; Sonja Yokum; Kenneth Blum; Cara Bohon |
Related Documents
:
|
23064178 - Novel bio-active lipid nanocarriers for the stabilization and sustained release of sito... 14739028 - Trypanosoma cruzi transmission in a captive primate unit, rio de janeiro, brazil. 9528118 - Hand use and gestural communication in chimpanzees (pan troglodytes). 20680018 - Taste, olfactory and food texture reward processing in the brain and obesity. 17370278 - Compostability of bioplastic packaging materials: an overview. 1522288 - Inhibition of plaque formation and gingivitis in beagle dogs by topical use of a degrad... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-30 Completed Date: 2010-10-25 Revised Date: 2011-07-25 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 13105-9 Citation Subset: IM |
Affiliation:
|
Department of Psychology, University of Texas, Austin, Texas 78712, USA. stice@psy.utexas.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Appetite Regulation
/
physiology* Appetitive Behavior / physiology Brain Mapping / methods Corpus Striatum / anatomy & histology, physiology* Female Humans Hyperphagia / physiopathology*, psychology Magnetic Resonance Imaging Neural Inhibition / physiology* Neuropsychological Tests Obesity / physiopathology*, psychology Prospective Studies Reward Weight Gain / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
DK080760/DK/NIDDK NIH HHS; R01 DK080760-01A2/DK/NIDDK NIH HHS; R01 DK080760-02/DK/NIDDK NIH HHS; R01 DK080760-03/DK/NIDDK NIH HHS; R01 MH064560-01A1/MH/NIMH NIH HHS; R01 MH064560-02/MH/NIMH NIH HHS; R01 MH064560-02S1/MH/NIMH NIH HHS; R01 MH064560-03/MH/NIMH NIH HHS; R01 MH064560-04/MH/NIMH NIH HHS; R01 MH064560-04S1/MH/NIMH NIH HHS; R01 MH064560-05/MH/NIMH NIH HHS; R1MH64560A/MH/NIMH NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The architecture of reward value coding in the human orbitofrontal cortex.
Next Document: Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement o...