Document Detail

Weight differences in rat embryos prior to sexual differentiation.
MedLine Citation:
PMID:  915426     Owner:  NLM     Status:  MEDLINE    
Sex of day-12 rat embryos was determined using Barr body counts made on spreads of amniotic membranes examined histologically. Embryonic weight, protein content and rate of thymidine incorporation were compared in male and female embryos. Male embryos were found to be heavier and accordingly to contain more protein on absolute but not on per unit weight basis. The rate of thymidine incorporation did not differ in the two sexes. Since gonadogenesis in day-12 rat embryos is rudimentary, with gonadal differentiation of sex not yet apparent, the increased weight suggests that sex-linked genes exist which influence body growth prior to gonadal endocrine activity.
W J Scott; J F Holson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of embryology and experimental morphology     Volume:  40     ISSN:  0022-0752     ISO Abbreviation:  J Embryol Exp Morphol     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906439     Medline TA:  J Embryol Exp Morphol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-63     Citation Subset:  IM    
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MeSH Terms
DNA / biosynthesis
Embryo, Mammalian / anatomy & histology*,  metabolism
Gestational Age
Proteins / metabolism
Sex Differentiation*
Sex Factors
Reg. No./Substance:
0/Proteins; 9007-49-2/DNA

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