| Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial. | |
| | |
MedLine Citation:
|
PMID: 22264468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: We determined the effect of weight loss on the prevalence, incidence and resolution of weekly or more frequent urinary incontinence in overweight/obese women with type 2 diabetes after 1 year of intervention in the Look AHEAD (Action for Health in Diabetes) trial. MATERIALS AND METHODS: Women in this substudy (2,739, mean ± SD age 57.9 ± 6.8 years, body mass index 36.5 ± 6.1 kg/m(2)) were randomized into an intensive lifestyle weight loss intervention or a diabetes support and education control condition. RESULTS: At baseline 27% of participants reported urinary incontinence on a validated questionnaire (no significant difference by intensive lifestyle intervention vs diabetes support and education). After 1 year of intervention the intensive lifestyle intervention group in this substudy lost 7.7 ± 7.0 vs 0.7 ± 5.0 kg in the diabetes support and education group. At 1 year fewer women in the intensive lifestyle intervention group reported urinary incontinence (25.3% vs 28.6% in the diabetes support and education group, p = 0.05). Among participants without urinary incontinence at baseline 10.5% of intensive lifestyle intervention and 14.0% of diabetes support and education participants experienced urinary incontinence after 1 year (p = 0.02). There were no significant group differences in the resolution of urinary incontinence (p >0.17). Each kg of weight lost was associated with a 3% reduction in the odds of urinary incontinence developing (p = 0.01), and weight losses of 5% to 10% reduced these odds by 47% (p = 0.002). CONCLUSIONS: Moderate weight loss reduced the incidence but did not improve the resolution rates of urinary incontinence at 1 year among overweight/obese women with type 2 diabetes. Weight loss interventions should be considered for the prevention of urinary incontinence in overweight/obese women with diabetes. |
| | |
Authors:
|
Suzanne Phelan; Alka M Kanaya; Leslee L Subak; Patricia E Hogan; Mark A Espeland; Rena R Wing; Kathryn L Burgio; Vicki DiLillo; Amy A Gorin; Delia S West; Jeanette S Brown; |
Related Documents
:
|
7569108 - Renal changes of streptozotocin-induced diabetic rats fed a low-zinc diet. 21333978 - Identification of a model of non-esterified fatty acids dynamics through genetic algori... 21537458 - Assessing and treating insulin resistance in women with polycystic ovarian syndrome. 2025268 - Liver and muscle-fat type glucose transporter gene expression in obese and diabetic rats. 962888 - Anti-ketogenic effect of glucose in the lactating cow deprived of food. 20046718 - Antihyperglycemic activity of various fractions of cassia auriculata linn. in alloxan d... |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-01-20 |
Journal Detail:
|
Title: The Journal of urology Volume: 187 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-13 Completed Date: 2012-04-03 Revised Date: 2012-05-10 |
Medline Journal Info:
|
Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
|
Languages: eng Pagination: 939-44 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Kinesiology Department, California Polytechnic State University, San Luis Obispo, California 93407-0386, USA. sphelan@calpoly.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00017953 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Chi-Square Distribution* Diabetes Mellitus, Type 2 / complications*, epidemiology, prevention & control* Female Humans Incidence Life Style Logistic Models Middle Aged Obesity / complications*, epidemiology, prevention & control* Prevalence Treatment Outcome United States / epidemiology Urinary Incontinence / epidemiology, etiology*, prevention & control* Weight Loss* |
| Grant Support | |
ID/Acronym/Agency:
|
DK 046204/DK/NIDDK NIH HHS; DK56990/DK/NIDDK NIH HHS; DK56992/DK/NIDDK NIH HHS; DK57002/DK/NIDDK NIH HHS; DK57008/DK/NIDDK NIH HHS; DK57078/DK/NIDDK NIH HHS; DK57131/DK/NIDDK NIH HHS; DK57135/DK/NIDDK NIH HHS; DK57136/DK/NIDDK NIH HHS; DK57149/DK/NIDDK NIH HHS; DK57151/DK/NIDDK NIH HHS; DK57154/DK/NIDDK NIH HHS; DK57171/DK/NIDDK NIH HHS; DK57177/DK/NIDDK NIH HHS; DK57178/DK/NIDDK NIH HHS; DK57182/DK/NIDDK NIH HHS; DK57219/DK/NIDDK NIH HHS; K24 DK080775/DK/NIDDK NIH HHS; M01 RR000056 44/RR/NCRR NIH HHS; M01 RR00051/RR/NCRR NIH HHS; M01-RR-01066/RR/NCRR NIH HHS; M01-RR-02719/RR/NCRR NIH HHS; M01RR00211-40/RR/NCRR NIH HHS; P30 DK48520/DK/NIDDK NIH HHS; PA-98-053//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Empirical Medical Therapy for Idiopathic Male Infertility: A Survey of the American Urological Assoc...
Next Document: Initial Experience and Results With a New Adjustable Transobturator Male System for the Treatment of...