Document Detail

Weight Gain and Serum TSH Increase within the Reference Range after Hemithyroidectomy Indicate Lowered Thyroid Function.
MedLine Citation:
PMID:  24959372     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Background. Weight gain is frequently reported after hemithyroidectomy but the significance is recently discussed. Therefore, the aim of the study was to examine changes in body weight of hemithyroidectomized patients and to evaluate if TSH increase within the reference range could be related to weight gain. Methods. In a controlled follow-up study, two years after hemithyroidectomy for benign euthyroid goiter, postoperative TSH and body weight of 28 patients were compared to preoperative values and further compared to the results in 47 matched control persons, after a comparable follow-up period. Results. Two years after hemithyroidectomy, median serum TSH was increased over preoperative levels (1.23 versus 2.08 mIU/L, P < 0.01) and patients had gained weight (75.0 versus 77.3 kg, P = 0.02). Matched healthy controls had unchanged median serum TSH (1.70 versus 1.60 mIU/L, P = 0.13) and weight (69.3 versus 69.3 kg, P = 0.71). Patients on thyroxin treatment did not gain weight. TSH increase was significantly correlated with weight gain (r = 0.43, P < 0.01). Conclusion. Two years after hemithyroidectomy for benign euthyroid goiter, thyroid function is lowered within the laboratory reference range. Weight gain of patients who are biochemically euthyroid after hemithyroidectomy may be a clinical manifestation of a permanently decreased metabolic rate.
Tina Toft Kristensen; Jacob Larsen; Palle Lyngsie Pedersen; Anne-Dorthe Feldthusen; Christina Ellervik; Søren Jelstrup; Jan Kvetny
Publication Detail:
Type:  Journal Article     Date:  2014-05-14
Journal Detail:
Title:  Journal of thyroid research     Volume:  2014     ISSN:  2090-8067     ISO Abbreviation:  J Thyroid Res     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-24     Completed Date:  2014-06-24     Revised Date:  2014-06-26    
Medline Journal Info:
Nlm Unique ID:  101536655     Medline TA:  J Thyroid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  892573     Citation Subset:  -    
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