Document Detail


Weight gain after lung reduction surgery is related to improved lung function and ventilatory efficiency.
MedLine Citation:
PMID:  22878279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Lung volume reduction surgery (LVRS) is associated with weight gain in some patients, but the group that gains weight after LVRS and the mechanisms underlying this phenomenon have not been well characterized.
OBJECTIVES: To describe the weight change profiles of LVRS patients enrolled in the National Emphysema Treatment Trial (NETT) and to correlate alterations in lung physiological parameters with changes in weight.
METHODS: We divided 1,077 non-high-risk patients in the NETT into groups according to baseline body mass index (BMI): underweight (<21 kg/m(2)), normal weight (21-25 kg/m(2)), overweight (25-30 kg/m(2)), and obese (>30 kg/m(2)). We compared BMI groups and LVRS and medical groups within each BMI stratum with respect to baseline characteristics and percent change in BMI (%ΔBMI) from baseline. We examined patients with (ΔBMI ≥ 5%) and without (ΔBMI < 5%) significant weight gain at 6 months and assessed changes in lung function and ventilatory efficiency (Ve/Vco(2)).
MEASUREMENTS AND MAIN RESULTS: The percent change in BMI was greater in the LVRS arm than in the medical arm in the underweight and normal weight groups at all follow-up time points, and at 12 and 24 months in the overweight group. In the LVRS group, patients with ΔBMI ≥ 5% at 6 months had greater improvements in FEV(1) (11.53 ± 9.31 vs. 6.58 ± 8.68%; P < 0.0001), FVC (17.51 ± 15.20 vs. 7.55 ± 14.88%; P < 0.0001), residual volume (-66.20 ± 40.26 vs. -47.06 ± 39.87%; P < 0.0001), 6-minute walk distance (38.70 ± 69.57 vs. 7.57 ± 73.37 m; P < 0.0001), maximal expiratory pressures (12.73 ± 49.08 vs. 3.54 ± 32.22; P = 0.0205), and Ve/Vco(2) (-1.58 ± 6.20 vs. 0.22 ± 8.20; P = 0.0306) at 6 months than patients with ΔBMI < 5% at 6 months.
CONCLUSIONS: LVRS leads to weight gain in nonobese patients, which is associated with improvement in lung function, exercise capacity, respiratory muscle strength, and ventilatory efficiency. These physiological changes may be partially responsible for weight gain in patients who undergo LVRS.
Authors:
Victor Kim; Dana M Kretschman; Alice L Sternberg; Malcolm M DeCamp; Gerard J Criner;
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2012-08-09
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  186     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-01     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1109-16     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Body Mass Index*
Body Weight
Exercise Tolerance / physiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Monitoring, Physiologic / methods
Multivariate Analysis
Odds Ratio
Pneumonectomy / methods*
Postoperative Care / methods
Prospective Studies
Pulmonary Disease, Chronic Obstructive / diagnosis*,  mortality,  surgery*
Quality of Life
Reference Values
Respiratory Function Tests
Severity of Illness Index
Survival Rate
Total Lung Capacity / physiology*
Treatment Outcome
Weight Gain / physiology*
Grant Support
ID/Acronym/Agency:
K23 HL094696/HL/NHLBI NIH HHS; N01HR76101/HR/NHLBI NIH HHS; N01HR76102/HR/NHLBI NIH HHS; N01HR76103/HR/NHLBI NIH HHS; N01HR76104/HR/NHLBI NIH HHS; N01HR76105/HR/NHLBI NIH HHS; N01HR76106/HR/NHLBI NIH HHS; N01HR76107/HR/NHLBI NIH HHS; N01HR76108/HR/NHLBI NIH HHS; N01HR76109/HR/NHLBI NIH HHS; N01HR76110/HR/NHLBI NIH HHS; N01HR76111/HR/NHLBI NIH HHS; N01HR76112/HR/NHLBI NIH HHS; N01HR76113/HR/NHLBI NIH HHS; N01HR76114/HR/NHLBI NIH HHS; N01HR76115/HR/NHLBI NIH HHS; N01HR76116/HR/NHLBI NIH HHS; N01HR76117/HR/NHLBI NIH HHS; N01HR76118/HR/NHLBI NIH HHS; N01HR76119/HR/NHLBI NIH HHS
Investigator
Investigator/Affiliation:
Alfred P Fishman / ; Betsy Ann Bozzarello / ; Ameena Al-Amin / ; Marcia Katz / ; Carolyn Wheeler / ; Elaine Baker / ; Peter Barnard / ; Phil Cagle / ; James Carter / ; Sophia Chatziioannou / ; Karla Conejo-Gonzales / ; Kimberly Dubose / ; John Haddad / ; David Hicks / ; Neal Kleiman / ; Mary Milburn-Barnes / ; Chinh Nguyen / ; Michael Reardon / ; Joseph Reeves-Viets / ; Steven Sax / ; Amir Sharafkhaneh / ; Owen Wilson / ; Christine Young / ; Rafael Espada / ; Rose Butanda / ; Minnie Ellisor / ; Pamela Fox / ; Katherine Hale / ; Everett Hood / ; Amy Jahn / ; Satish Jhingran / ; Karen King / ; Charles Miller / ; Imran Nizami / ; Todd Officer / ; Jeannie Ricketts / ; Joe Rodarte / ; Robert Teague / ; Kedren Williams / ; John Reilly / ; David Sugarbaker / ; Carol Fanning / ; Simon Body / ; Sabine Duffy / ; Vladmir Formanek / ; Anne Fuhlbrigge / ; Philip Hartigan / ; Sarah Hooper / ; Andetta Hunsaker / ; Francine Jacobson / ; Marilyn Moy / ; Susan Peterson / ; Roger Russell / ; Diane Saunders / ; Scott Swanson / ; Rob McKenna / ; Zab Mohsenifar / ; Carol Geaga / ; Manmohan Biring / ; Susan Clark / ; Jennifer Cutler / ; Robert Frantz / ; Peter Julien / ; Michael Lewis / ; Jennifer Minkoff-Rau / ; Valentina Yegyan / ; Milton Joyner / ; Malcolm DeCamp / ; James Stoller / ; Yvonne Meli / ; John Apostolakis / ; Darryl Atwell / ; Jeffrey Chapman / ; Pierre DeVilliers / ; Raed Dweik / ; Erik Kraenzler / ; Rosemary Lann / ; Nancy Kurokawa / ; Scott Marlow / ; Kevin McCarthy / ; Priscilla McCreight / ; Atul Mehta / ; Moulay Meziane / ; Omar Minai / ; Mindi Steiger / ; Kenneth White / ; Janet Maurer / ; Terri Durr / ; Charles Hearn / ; Susan Lubell / ; Peter O'Donovan / ; Robert Schilz / ; Mark Ginsburg / ; Byron Thomashow / ; Patricia Jellen / ; John Austin / ; Matthew Bartels / ; Yahya Berkmen / ; Patricia Berkoski / ; Frances Brogan / ; Amy Chong / ; Glenda DeMercado / ; Angela DiMango / ; Sandy Do / ; Bessie Kachulis / ; Arfa Khan / ; Berend Mets / ; Mitchell O'Shea / ; Gregory Pearson / ; Leonard Rossoff / ; Steven Scharf / ; Maria Shiau / ; Paul Simonelli / ; Kim Stavrolakes / ; Donna Tsang / ; Denise Vilotijevic / ; Chun Yip / ; Mike Mantinaos / ; Kerri McKeon / ; Jacqueline Pfeffer / ; Neil MacIntyre / ; R Duane Davis / ; John Howe / ; R Edward Coleman / ; Rebecca Crouch / ; Dora Greene / ; Katherine Grichnik / ; David Harpole / ; Abby Krichman / ; Brian Lawlor / ; Holman McAdams / ; John Plankeel / ; Susan Rinaldo-Gallo / ; Sheila Shearer / ; Jeanne Smith / ; Mark Stafford-Smith / ; Victor Tapson / ; Mark Steele / ; Jennifer Norten / ; James Utz / ; Claude Deschamps / ; Kathy Mieras / ; Martin Abel / ; Mark Allen / ; Deb Andrist / ; Gregory Aughenbaugh / ; Sharon Bendel / ; Eric Edell / ; Marlene Edgar / ; Bonnie Edwards / ; Beth Elliot / ; James Garrett / ; Delmar Gillespie / ; Judd Gurney / ; Boleyn Hammel / ; Karen Hanson / ; Lori Hanson / ; Gordon Harms / ; June Hart / ; Thomas Hartman / ; Robert Hyatt / ; Eric Jensen / ; Nicole Jenson / ; Sanjay Kalra / ; Philip Karsell / ; Jennifer Lamb / ; David Midthun / ; Carl Mottram / ; Stephen Swensen / ; Anne-Marie Sykes / ; Karen Taylor / ; Norman Torres / ; Rolf Hubmayr / ; Daniel Miller / ; Sara Bartling / ; Kris Bradt / ; Barry Make / ; Marvin Pomerantz / ; Mary Gilmartin / ; Joyce Canterbury / ; Martin Carlos / ; Phyllis Dibbern / ; Enrique Fernandez / ; Lisa Geyman / ; Connie Hudson / ; David Lynch / ; John Newell / ; Robert Quaife / ; Jennifer Propst / ; Cynthia Raymond / ; Jane Whalen-Price / ; Kathy Winner / ; Martin Zamora / ; Reuben Cherniack / ; Philip Diaz / ; Patrick Ross / ; Tina Bees / ; Jan Drake / ; Charles Emery / ; Mark Gerhardt / ; Mark King / ; David Rittinger / ; Mahasti Rittinger / ; Saint Louis / ; Keith Naunheim / ; Robert Gerber / ; Joan Osterloh / ; Susan Borosh / ; Willard Chamberlain / ; Sally Frese / ; Alan Hibbit / ; Mary Ellen Kleinhenz / ; Gregg Ruppel / ; Cary Stolar / ; Janice Willey / ; Francisco Alvarez / ; Cesar Keller / ; Gerard Criner / ; Satoshi Furukawa / ; Anne Marie Kuzma / ; Roger Barnette / ; Neil Brister / ; Kevin Carney / ; Wissam Chatila / ; Francis Cordova / ; Gilbert D'Alonzo / ; Michael Keresztury / ; Karen Kirsch / ; Chul Kwak / ; Kathy Lautensack / ; Madelina Lorenzon / ; Ubaldo Martin / ; Peter Rising / ; Scott Schartel / ; John Travaline / ; Gwendolyn Vance / ; Phillip Boiselle / ; Gerald O'Brien / ; Andrew Ries / ; Robert Kaplan / ; Catherine Ramirez / ; David Frankville / ; Paul Friedman / ; James Harrell / ; Jeffery Johnson / ; David Kapelanski / ; David Kupferberg / ; Catherine Larsen / ; Trina Limberg / ; Michael Magliocca / ; Frank J Papatheofanis / ; Dawn Sassi-Dambron / ; Melissa Weeks / ; Mark Krasna / ; Henry Fessler / ; Iris Moskowitz / ; Timothy Gilbert / ; Jonathan Orens / ; Steven Scharf / ; David Shade / ; Stanley Siegelman / ; Kenneth Silver / ; Clarence Weir / ; Charles White / ; Fernando Martinez / ; Mark Iannettoni / ; Catherine Meldrum / ; William Bria / ; Kelly Campbell / ; Paul Christensen / ; Kevin Flaherty / ; Steven Gay / ; Paramjit Gill / ; Paul Kazanjian / ; Ella Kazerooni / ; Vivian Knieper / ; Tammy Ojo / ; Lewis Poole / ; Leslie Quint / ; Paul Rysso / ; Thomas Sisson / ; Mercedes True / ; Brian Woodcock / ; Lori Zaremba / ; Larry Kaiser / ; John Hansen-Flaschen / ; Mary Louise Dempsey / ; Abass Alavi / ; Theresa Alcorn / ; Selim Arcasoy / ; Judith Aronchick / ; Stanley Aukberg / ; Bryan Benedict / ; Susan Craemer / ; Ron Daniele / ; Jeffrey Edelman / ; Warren Gefter / ; Laura Kotler-Klein / ; Robert Kotloff / ; David Lipson / ; Wallace Miller / ; Richard O'Connell / ; Staci Opelman / ; Harold Palevsky / ; William Russell / ; Heather Sheaffer / ; Rodney Simcox / ; Susanne Snedeker / ; Jennifer Stone-Wynne / ; Gregory Tino / ; Peter Wahl / ; James Walter / ; Patricia Ward / ; David Zisman / ; James Mendez / ; Angela Wurster / ; Frank Sciurba / ; James Luketich / ; Colleen Witt / ; Gerald Ayres / ; Michael Donahoe / ; Carl Fuhrman / ; Robert Hoffman / ; Joan Lacomis / ; Joan Sexton / ; William Slivka / ; Diane Strollo / ; Erin Sullivan / ; Tomeka Simon / ; Catherine Wrona / ; Gerene Bauldoff / ; Manuel Brown / ; Elisabeth George / ; Robert Keenan / ; Theodore Kopp / ; Laurie Silfies / ; Joshua Benditt / ; Douglas Wood / ; Margaret Snyder / ; Kymberley Anable / ; Nancy Battaglia / ; Louie Boitano / ; Andrew Bowdle / ; Leighton Chan / ; Cindy Chwalik / ; Bruce Culver / ; Thurman Gillespy / ; David Godwin / ; Jeanne Hoffman / ; Andra Ibrahim / ; Diane Lockhart / ; Stephen Marglin / ; Kenneth Martay / ; Patricia McDowell / ; Donald Oxorn / ; Liz Roessler / ; Michelle Toshima / ; Susan Golden / ; Lynn Bosco / ; Yen-Pin Chiang / ; Carolyn Clancy / ; Harry Handelsman / ; Steven M Berkowitz / ; Tanisha Carino / ; Joe Chin / ; JoAnna Baldwin / ; Karen McVearry / ; Anthony Norris / ; Sarah Shirey / ; Claudette Sikora / ; Steven Sheingold / ; Steven Piantadosi / ; James Tonascia / ; Patricia Belt / ; Amanda Blackford / ; Karen Collins / ; Betty Collison / ; Ryan Colvin / ; John Dodge / ; Michele Donithan / ; Vera Edmonds / ; Gregory L Foster / ; Julie Fuller / ; Judith Harle / ; Rosetta Jackson / ; Shing Lee / ; Charlene Levine / ; Hope Livingston / ; Jill Meinert / ; Jennifer Meyers / ; Deborah Nowakowski / ; Kapreena Owens / ; Shangqian Qi / ; Michael Smith / ; Brett Simon / ; Paul Smith / ; Alice Sternberg / ; Mark Van Natta / ; Laura Wilson / ; Robert Wise / ; Robert M Kaplan / ; Sanford J Schwartz / ; Yen-Pin Chiang / ; Marianne C Fahs / ; A Mark Fendrick / ; Alan J Moskowitz / ; Dev Pathak / ; Scott Ramsey / ; Steven Sheingold / ; A Laurie Shroyer / ; Judith Wagner / ; Roger Yusen / ; Scott Ramsey / ; Ruth Etzioni / ; Sean Sullivan / ; DouglasWood / ; Thomas Schroeder / ; Karma Kreizenbeck / ; Kristin Berry / ; Nadia Howlader / ; Eric Hoffman / ; Janice Cook-Granroth / ; Angela Delsing / ; Junfeng Guo / ; Geoffrey McLennan / ; Brian Mullan / ; Chris Piker / ; Joseph Reinhardt / ; Blake Wood / ; Jered Sieren / ; William Stanford / ; John A Waldhausen / ; Gordon Bernard / ; David DeMets / ; Mark Ferguson / ; Eddie Hoover / ; Robert Levine / ; Donald Mahler / ; A John McSweeny / ; Jeanine Wiener-Kronish / ; O Dale Williams / ; Magdy Younes / ; Gerard Criner / ; Charles Soltoff / ; Gail Weinmann / ; Joanne Deshler / ; Dean Follmann / ; James Kiley / ; Margaret Wu /
Comments/Corrections
Comment In:
Am J Respir Crit Care Med. 2012 Dec 1;186(11):1068-70   [PMID:  23204369 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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