Document Detail


Weight Gain After Lung Reduction Surgery is Related to Improved Lung Function and Ventilatory Efficiency.
MedLine Citation:
PMID:  22878279     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Lung volume reduction surgery (LVRS) is associated with weight gain in some patients, but the group that gains weight after LVRS and the mechanisms underlying this phenomenon have not been well characterized. METHODS: We divided 1077 non-high risk patients in the National Emphysema Treatment Trial into groups according to baseline body mass index (BMI): Underweight (<21kg/m2), Normal Weight (21-25kg/m2), Overweight (25-30kg/m2), and Obese (>30kg/m2). We compared BMI groups and LVRS and medical groups within each BMI stratum with respect to baseline characteristics and percent change in BMI (%BMI) from baseline. We examined patients with (BMI≥5%) and without (BMI<5%) significant weight gain at 6 months and assessed changes in lung function and ventilatory efficiency (VE/VCO2). RESULTS: %BMI was greater in the LVRS arm than Medical arm in the Underweight and Normal Weight groups at all follow-up timepoints, and at 12 and 24 months in the Overweight group. In the LVRS group, patients with BMI≥5% at 6 months had greater improvements in FEV1 (11.53±9.31 vs. 6.58±8.68%, p<0.0001), FVC ±15.20 vs. 7.55±14.88%, p<0.0001), RV (±40.26 vs. -47.06±39.87%, p<0.0001), 6-minute walk distance (38.70±69.57 vs±73.37 meters, p<0.0001), maximal expiratory pressures (12.73±49.08 vs±32.22, p=0.0205), and VE/VCO2 (-1.58±6.20 vs±8.20, p=0.0306) at 6 months than patients with BMI<5% at 6 months. CONCLUSIONS: LVRS leads to weight gain in nonobese patients, which is associated with improvement in lung function, exercise capacity, respiratory muscle strength, and ventilatory efficiency. These physiologic changes may be partially responsible for weight gain in patients who undergo LVRS.
Authors:
Victor Kim; Dana M Kretschman; Alice L Sternberg; Malcolm M Decamp; Gerard J Criner;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  -     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Pulmonary and Critical Care Medicine, Temple University, Philadelphia, Pennsylvania, United States.
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