Document Detail


Weighing in ocular perfusion pressure in managing glaucoma.
MedLine Citation:
PMID:  19816588     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The role of vascular risk factors in glaucoma is increasingly being supported by the literature, with the association between low ocular perfusion pressure (PP) and glaucoma being the most consistent result. However, we need to be cautious when interpreting these results and consider all possible confounders in the observed associations. While we assess PP through its principal components, the weight of intraocular pressure (IOP) and blood pressure (BP) in the PP equation remains unknown. Also, the role of PP in glaucoma needs to be elucidated with regards to IOP and BP fluctuation during the 24hour period and the effect of IOP-lowering and BP-lowering treatment. The complexity of the interaction of PP with other potential risk factors for glaucoma means that PP cannot be currently considered in the assessment of an individual patient. The role of PP in glaucoma warrants further research and randomized clinical trials assessing PP should include vision and/or structure preservation as end-points and ideally address all of the above issues.
Authors:
Fotis Topouzis; Panayiota Founti
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Publication Detail:
Type:  Journal Article     Date:  2009-09-17
Journal Detail:
Title:  The open ophthalmology journal     Volume:  3     ISSN:  1874-3641     ISO Abbreviation:  Open Ophthalmol J     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101480505     Medline TA:  Open Ophthalmol J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-5     Citation Subset:  -    
Affiliation:
A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
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