Document Detail

Wegener's granulomatosis.
MedLine Citation:
PMID:  2043454     Owner:  NLM     Status:  MEDLINE    
Wegner's granulomatosis is a clinicopathologic syndrome of unknown etiology characterized by granulomatous vasculitis of the upper and lower respiratory tracts and glomerulonephritis. During the period covered by this review several articles were published describing the clinical and pathologic features of Wegner's granulomatosis. Specifically, two large series are discussed reviewing the pulmonary manifestations of the disease and the histopathology of the head and neck disease associated with Wegner's granulomatosis. The majority of publications related to Wegner's granulomatosis concern anti-neutrophil cytoplasmic antibodies and their role in the diagnosis, management, and pathogenesis of Wegner's granulomatosis. In the period covered by this article, no new reports on the therapy of Wegner's granulomatosis were reviewed. However, two articles that address the efficacy of cyclophosphamide pulse therapy in Wegner's granulomatosis have recently been published with conflicting conclusions. The data from these articles are mentioned but will be reviewed in more detail in a subsequent article.
R Y Leavitt; A S Fauci
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  3     ISSN:  1040-8711     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-07-12     Completed Date:  1991-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  IM    
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
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MeSH Terms
Cyclophosphamide / therapeutic use
Wegener Granulomatosis / drug therapy,  immunology,  pathology*
Reg. No./Substance:

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