Document Detail

Wegener's granulomatosis presenting during pregnancy with acute limb ischemia.
MedLine Citation:
PMID:  16242573     Owner:  NLM     Status:  MEDLINE    
We report a rare case of a pregnant woman with Wegener's granulomatosis whose disease involved the lungs, the spleen, and a limb. Wegener's granulomatosis was clinically manifested in the 34th week of pregnancy with pulmonary infiltrates, splenic infarcts, and acute limb ischemia. Successive thrombectomies failed to maintain arterial flow in the distal limb due to the development of active vasculitis. Thrombosis of the tibial arteries and recurrence of thrombosis was a persistent clinical observation. In the meantime, a cesarean section was performed, with a successful delivery of a healthy male newborn. Because of the recent cesarean section, the patient did not undergo thrombolysis. The woman finally underwent amputation of the limb. According to the reviewed literature, this is the sixth reported case of Wegener's granulomatosis presenting with digital ischemia and the first manifested during pregnancy.
Nikolaos Bessias; Konstantinos G Moulakakis; Christos Lioupis; Konstantinos Bakogiannis; Giorgos Sfyroeras; Konstantina Kakaletri; Vassilios Andrikopoulos
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  42     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-24     Completed Date:  2005-12-01     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  800-4     Citation Subset:  IM    
Department of Vascular Surgery, Red Cross Hospital, Athens, Greece.
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MeSH Terms
Acute Disease
Amputation / methods*
Follow-Up Studies
Ischemia / etiology*,  radiography,  surgery
Leg / blood supply*
Popliteal Artery / physiopathology*,  radiography
Pregnancy Complications / diagnosis*
Pregnancy Outcome
Pregnancy Trimester, Third
Wegener Granulomatosis / complications,  diagnosis*

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