Document Detail

Wegener's granulomatosis presenting as mediastinal soft tissue mass invading the tracheal wall.
MedLine Citation:
PMID:  11147766     Owner:  NLM     Status:  MEDLINE    
Wegener's granulomatosis (WG) is a clinicopathologic entity of unknown cause characterised by a necrotising granulomatous vasculitis affecting multiple organs, especially the upper and lower respiratory tracts, lung and kidney. The lung is the most frequently, and sometimes the only involved organ. Single or multiple nodules, with or without cavitation, are the most common pulmonary manifestations in WG, but mediastinal involvement is atypical. The sole tracheal involvement is rare and hilar and mediastinal involvement has been thought not to be part of the clinical feature. We experienced a rare case of WG presenting as paratracheal mediastinal lesions with tracheal wall invasion, which responded dramatically to corticosteroid treatment. We present this case with a review of the literature.
Y H Song; T H Kim; I H Lee; S C Yang; C K Park; S J Jang; S Y Kim
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  19     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-05     Completed Date:  2001-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  495-8     Citation Subset:  IM    
The Hospital for Rheumatic Diseases, Department of Internal Medicine, Hanyang University Medical Center, Seoul, Korea.
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MeSH Terms
Disease Progression
Mediastinal Diseases / drug therapy,  etiology*,  pathology*
Methotrexate / administration & dosage
Steroids / administration & dosage
Trachea / pathology*,  radiography
Tracheal Diseases / drug therapy,  etiology*,  pathology*
Treatment Outcome
Wegener Granulomatosis / complications*,  drug therapy,  pathology*
Reg. No./Substance:
0/Steroids; 59-05-2/Methotrexate

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