Document Detail

Wegener's granulomatosis - another challenging case.
MedLine Citation:
PMID:  22689609     Owner:  NLM     Status:  In-Data-Review    
A 54-year-old lady initially presented with mild dyspnoea, left-sided flank pain and bilateral leg swelling. She was diagnosed as having single vessel coronary heart disease. Subsequently, this lady developed malaise, joint aches, an aspecific skin rash and limbal conjunctivitis. She was thought to have Löfgren's syndrome. The patient then developed sore throats and petechiae, later severe dyspnoea with sanguineous expectoration and light nasal bleeds. Cytoplasm-antineutrophil cytoplasmic autoantibodies and proteinase 3-ANCA were determined, found positive and she was diagnosed as having Wegener's granulomatosis. This was at 3 months after her initial presentation. She was treated with pulsed intravenous Cyclophosphamide and oral prednisolone. The patient improved quickly and the medication was changed to oral methotrexate and prednisolone. Currently, the patient is doing well and is in remission.
Henricus van den Heuvel
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Publication Detail:
Type:  Journal Article     Date:  2011-07-20
Journal Detail:
Title:  BMJ case reports     Volume:  2011     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2011  
Date Detail:
Created Date:  2012-06-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
BFG HS, Gutersloh, Germany.
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