Document Detail

Wegener granulomatosis simulating bacterial endocarditis.
MedLine Citation:
PMID:  10448786     Owner:  NLM     Status:  MEDLINE    
Cardiac involvement in Wegener granulomatosis is uncommon. We report a case of Wegener granulomatosis that presented as culture-negative endocarditis with aortic valvular vegetation. The clinical manifestations included gingival hyperplasia, gangrenous digital infarcts, mononeuritis multiplex, high fever, inflammatory arthritis, pansinusitis, splenic infarct, and aortic valvular vegetation, which underscore the difficulty of distinguishing systemic vasculitis from bacterial endocarditis. Contrary to the common notion that valvular vegetation is invariably associated with bacterial endocarditis, this case proves that such findings can occur in Wegener granulomatosis as well. Clinicians are guided toward early treatment with corticosteroids and cyclophosphamide to prevent fatal complications.
D D Anthony; A D Askari; T Wolpaw; G McComsey
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  159     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:    1999 Aug 9-23
Date Detail:
Created Date:  1999-08-26     Completed Date:  1999-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1807-10     Citation Subset:  AIM; IM    
Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Ohio 44106, USA.
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MeSH Terms
Aortic Valve
Diagnosis, Differential
Endocarditis, Bacterial / diagnosis,  etiology
Fingers / blood supply
Gingival Hyperplasia / etiology
Heart Valve Diseases / diagnosis*,  etiology*,  pathology
Infarction / etiology
Middle Aged
Wegener Granulomatosis / complications*,  diagnosis*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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