| Weekly psoriasis therapy using intralesional fluorouracil. | |
| | |
MedLine Citation:
|
PMID: 3301925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report the use of weekly intralesional fluorouracil for treatment of entire psoriatic papules and portions of larger psoriatic plaques. Eleven patients participated and responded, with an average of 4.2 cm2 clearing about the injection site in the treated lesions, in comparison with no improvement in the control lesions. We injected 1 ml of fluorouracil (50 mg/ml) to form an intradermal wheal of about 0.8 cm2. Each patient received one to three injections at 1- to 2-week intervals, with an average of two injections per patient. The earliest signs of improvement occurred at 2 weeks; maximum clearing was achieved usually about 4 weeks after treatment began. At 3-month follow-up, four of the nine patients who had favorable response to treatment remained substantially in remission. Toxic effects were limited to local hyperpigmentation in seven patients, slight irritation in two patients, and moderate irritation in one patient. No systemic toxic effects were shown. Weekly pulse doses of fluorouracil given intralesionally instead of topically can greatly speed up response to therapy and can produce similarly good results. Intralesional administration of fluorouracil is locally effective, is often of long-term benefit, and can be tolerated well. |
| | |
Authors:
|
D L Pearlman; B Youngberg; C Engelhard |
Related Documents
:
|
19998345 - Calcium hydroxylapatite injection laryngoplasty for the treatment of presbylaryngis: lo... 17890635 - Botulinum injections for the treatment of bladder symptoms of multiple sclerosis. 20399985 - Effects of high-dose ziprasidone and haloperidol on the qtc interval after intramuscula... 20460215 - Therapeutic efficacy of botulinum toxin in the treatment of urinary incontinence in fem... 11409115 - Long-term safety and efficacy of etanercept in patients with rheumatoid arthritis. 8265095 - Ondansetron compared with granisetron in the prophylaxis of cisplatin-induced acute eme... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American Academy of Dermatology Volume: 17 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1987 Jul |
Date Detail:
|
Created Date: 1987-09-09 Completed Date: 1987-09-09 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 78-82 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Adult Clinical Trials as Topic Double-Blind Method Female Fluorouracil / administration & dosage*, adverse effects, therapeutic use Humans Injections Male Middle Aged Psoriasis / drug therapy* Random Allocation Time Factors |
| Chemical | |
Reg. No./Substance:
|
51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alopecia areata, endocrine function, and autoantibodies in patients 16 years of age or younger.
Next Document: Topical minoxidil in male pattern baldness: effects of discontinuation of treatment.