Document Detail

Weaning and outcome from mechanical ventilation.
MedLine Citation:
PMID:  7711709     Owner:  NLM     Status:  MEDLINE    
Weaning means the ability of a patient to breath spontaneously after mechanical ventilation. In chronic obstructive pulmonary disease (COPD) patients, inability to tolerate discontinuation of mechanical ventilation is reported to have an incidence of 25-60%. It is, therefore, important to employ simple parameters able to predict weaning success, since, in the case of failure, the validation of predictive indices of weaning may also contribute to the decision of whether or not these patients should eventually enter a programme of home ventilation. Among other indices employed, respiratory frequency/tidal volume (f/VT) ratio, compliance, rate, oxygenation and pressure (CROP) index, mouth occlusion pressure (P0.1) and static compliance of the respiratory system have been shown to be quite accurate. The survival at one year of these patients requiring mechanical ventilation ranges 34-49%. Indeed, there is a particular subset of COPD patients in whom mechanical ventilation is prolonged due to the severity of their pathology. We studied 42 of these patients requiring mechanical ventilation for more than 21 days, to assess with simple parameters (arterial blood gases, pulmonary function tests, respiratory muscle force, P0.1, nutritional status) their potential for weaning and their survival at 2 yrs. Using discriminant analysis, and employing an equation comprising maximal inspiratory pressure (MIP) and arterial carbon dioxide tension (PaCO2), we were able to predict the patients able or unable to be weaned with an accuracy of almost 85%.(ABSTRACT TRUNCATED AT 250 WORDS)
S Nava; E Zanotti; F Rubini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo     Volume:  49     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-15     Completed Date:  1995-05-15     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  530-2     Citation Subset:  IM    
Division of Pneumology, Centro Medico di Riabilitazione di Montescano, Fondazione Clinica del Lavoro, IRCCS, Italy.
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MeSH Terms
Lung Diseases, Obstructive / therapy*
Treatment Outcome
Ventilator Weaning*

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