| Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine. | |
| | |
MedLine Citation:
|
PMID: 15333713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study investigated intestinal physiology of piglets at weaning. Piglets (n = 60) weaned at 21 d were food deprived for 2 d and then tube-fed using 2 different diets (a conventional diet vs. a wheat-enriched diet). They were slaughtered at d 0, 2, 5, 8, or 15 postweaning. Jejunum, ileum, and colon were mounted in Ussing chambers. In addition, segments of the proximal jejunum of 4 growing pigs were studied 35 d after weaning. Secretory function was assessed by basal short-circuit current (Isc) and secretagogue-stimulated Isc. Glucose absorption was measured by the increase in Isc after the addition of glucose. Epithelial barrier function was measured by transmucosal resistance (R) and horseradish peroxidase (HRP) fluxes across the epithelium. There were no significant differences between the pigs fed the 2 diets for any of the parameters studied. As already reported, a transient villous atrophy was observed. At the same time, we observed an increased basal Isc in jejunum and colon, increased glucose absorption and a dramatic drop of R in jejunum. These parameters had returned to preweaning values by d 5. Weaning was also followed by long-lasting modifications. In jejunum, responses to the secretagogues and glucose absorption were decreased at wk 2 after weaning and were not different between d 15 and 35. Ileal transmucosal resistance increased on d 5 and was stable thereafter. HRP flux in jejunum declined on d 2 and stayed at this low level throughout the experiment. We conclude that weaning induces transient dramatic changes in intestinal physiology but is also a period of maturation of the intestine. |
| | |
Authors:
|
Gaëlle Boudry; Vincent Péron; Isabelle Le Huërou-Luron; Jean Paul Lallès; Bernard Sève |
Related Documents
:
|
9270983 - Refeeding varying fatty acid and cholesterol diets alters phospholipids in rat intestin... 12755303 - Dimensions and histologic characteristics of the small intestine of dogs during postnat... 11286283 - L-carnitine supplementation in breeding pigeons: impact on zootechnical performance and... |
Publication Detail:
|
Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of nutrition Volume: 134 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2004 Sep |
Date Detail:
|
Created Date: 2004-08-30 Completed Date: 2004-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 2256-62 Citation Subset: IM |
Affiliation:
|
Institut National de la Recherche Agronomique (INRA)-UMRVP, St-Gilles, France. Gaelle.boudry@rennes.inra.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
metabolism Animals Animals, Newborn / growth & development, physiology* Colon / metabolism Diet Glucose / metabolism Ileum / anatomy & histology, enzymology Intestinal Absorption* Intestinal Mucosa / metabolism Intestines / metabolism* Jejunum / anatomy & histology, enzymology Macromolecular Substances Permeability Sodium / metabolism Swine Weaning* |
| Chemical | |
Reg. No./Substance:
|
0/Macromolecular Substances; 50-99-7/Glucose; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dietary iron affects inflammatory status in a rat model of colitis.
Next Document: Cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers do not modify body composition...