| Weak peristalsis in esophageal pressure topography: classification and association with Dysphagia. | |
| | |
MedLine Citation:
|
PMID: 20924368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Esophageal manometry is frequently used to assess for weak peristalsis. Although commonly used clinically, there are currently no validated metrics of weak peristalsis in high-resolution esophageal pressure topography (EPT). This study aimed to develop a classification of weak peristalsis in EPT based on a comparative analysis of control subjects and patients with unexplained non-obstructive dysphagia. METHODS: High-resolution esophageal pressure topography (high-resolution impedance manometry) studies were carried out in 16 control subjects to verify EPT features associated with incomplete bolus transit (IBT). The technique of superimposing EPT plots in a computer simulation was used to derive normal limits of peristaltic integrity in EPT in another 75 control subjects. The occurrence of critical EPT defects was then compared between control subjects and 113 patients with non-obstructive dysphagia identified from a large clinical series. RESULTS: IBT occurred with failed peristalsis or with breaks in the 20 mm Hg isobaric contour occurring at the proximal or distal pressure troughs in EPT plots. The normal range for isobaric contour breaks was 0-20% for large (>5 cm) and 0-30% for small (2-5 cm) breaks, with both occurring significantly more frequently in dysphagic patients. Failed peristalsis was not more frequent in dysphagic patients. CONCLUSIONS: A classification of weak peristalsis adapted to EPT is proposed based on the occurrence of breaks in the 20 mm Hg isobaric contour wherein weak peristalsis with large breaks is defined by those occurring with >20% of swallows and weak peristalsis with small breaks defined by those occurring with >30% of swallows. |
| | |
Authors:
|
Sabine Roman; Zhiyue Lin; Monika A Kwiatek; John E Pandolfino; Peter J Kahrilas |
Related Documents
:
|
8116128 - Gastric muscularis as a urinary sphincter. 7886398 - The effect of cisapride and metoclopramide on human digestive and interdigestive antrod... 17266688 - Pharmacotherapy for the prevention of post-ercp pancreatitis. 21510728 - Hemodynamic monitoring in pulmonary arterial hypertension. 20175248 - Assessment of differences in some indicators of pain in double muscled belgian blue cow... 489268 - Absolute lung density in experimental canine pulmonary edema. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-05 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 106 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-08 Completed Date: 2011-04-20 Revised Date: 2011-11-09 |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 349-56 Citation Subset: IM |
Affiliation:
|
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611-2951, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Case-Control Studies Chi-Square Distribution Computer Simulation Deglutition Disorders / physiopathology* Esophageal Motility Disorders / physiopathology* Female Humans Male Manometry Middle Aged Peristalsis / physiology* Pressure Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
|
R01 DK056033-09/DK/NIDDK NIH HHS; R01 DK079902/DK/NIDDK NIH HHS; R01 DK079902-02/DK/NIDDK NIH HHS; R01 DK079902-03/DK/NIDDK NIH HHS; R01 DK56033/DK/NIDDK NIH HHS |
| Comments/Corrections | |
Comment In:
|
Am J Gastroenterol. 2011 Oct;106(10):1854-6; author reply 1856-7
[PMID:
21979209
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diagnosis and management of iron deficiency anemia in patients with IBD.
Next Document: IL28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: the future ...